The influence of dizocilpine (MK-801) on the reserpine-enhanced electromyographic stretch reflex in rats

被引：15

作者：

Ossowska, K ^{[1
]}

LorencKoci, E ^{[1
]}

Schulze, C ^{[1
]}

Wolfarth, S ^{[1
]}

机构：

[1] FREE UNIV BERLIN,INST NEUROPSYCHOPHARMACOL,W-1000 BERLIN,GERMANY

来源：

NEUROSCIENCE LETTERS | 1996年 / 203卷 / 02期

关键词：

NMDA receptors MK-801; stretch reflex; electromyogram; reserpine; Parkinsonian rigidity; rat;

D O I：

10.1016/0304-3940(95)12264-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The electromyographic (EMG) stretch reflex in the gastrocnemius and tibialis anterior muscles was elicited by passive bending and stretching of the rat's hind foot in the ankle joint. The EMG stretch reflex was increased by pretreatment with reserpine (10 mg/kg ip) which is a model compound commonly used to induce parkinsonian rigidity in laboratory animals. Dizocilpine (MK-801) (0.32, 0.64 and 1.28 mg/kg sc) inhibited long-latency supraspinal components of the reserpine-increased EMG stretch reflex, whereas a short latency spinal component was not diminished. The present results suggest that MK-801 exhibits an antiparkinsonian action against reserpine-induced rigidity.

引用

页码：73 / 76

页数：4