Quantitative analysis of population-scale family trees with millions of relatives

被引：132

作者：

Kaplanis, Joanna ^{[1
,2
]}

Gordon, Assaf ^{[1
,2
]}

Shor, Tal ^{[3
,4
]}

Weissbrod, Omer ^{[5
]}

Geiger, Dan ^{[4
]}

Wahl, Mary ^{[1
,2
,6
]}

Gershovits, Michael ^{[2
]}

Markus, Barak ^{[2
]}

Sheikh, Mona ^{[2
]}

Gymrek, Melissa ^{[1
,2
,7
,8
,9
]}

Bhatia, Gaurav ^{[10
,11
]}

MacArthur, Daniel G. ^{[7
,9
,10
]}

Price, Alkes L. ^{[10
,11
,12
]}

Erlich, Yaniv ^{[1
,2
,3
,13
,14
]}

机构：

[1] New York Genome Ctr, New York, NY 10013 USA

[2] Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA

[3] MyHeritage, IL-6037606 Or Yehuda, Israel

[4] Technion Israel Inst Technol, Comp Sci Dept, IL-3200003 Haifa, Israel

[5] Weizmann Inst Sci, Comp Sci Dept, IL-7610001 Rehovot, Israel

[6] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[7] Harvard Med Sch, Boston, MA 02115 USA

[8] Harvard MIT Program Hlth Sci & Technol, Cambridge, MA 02142 USA

[9] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA

[10] Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA

[11] Harvard Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[12] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[13] Columbia Univ, Dept Comp Sci, Fu Fdn Sch Engn, New York, NY 10027 USA

[14] Columbia Univ, Dept Syst Biol, Ctr Computat Biol & Bioinformat, New York, NY 10027 USA

来源：

SCIENCE | 2018年 / 360卷 / 6385期

关键词：

GENE INTERACTIONS; HUMAN LONGEVITY; COMPLEX TRAITS; LIFE-SPAN; HERITABILITY; ASSOCIATION; HISTORY; FERTILITY; EPISTASIS; ERA;

D O I：

10.1126/science.aam9309

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Family trees have vast applications in fields as diverse as genetics, anthropology, and economics. However, the collection of extended family trees is tedious and usually relies on resources with limited geographical scope and complex data usage restrictions. We collected 86 million profiles from publicly available online data shared by genealogy enthusiasts. After extensive cleaning and validation, we obtained population-scale family trees, including a single pedigree of 13 million individuals. We leveraged the data to partition the genetic architecture of human longevity and to provide insights into the geographical dispersion of families. We also report a simple digital procedure to overlay other data sets with our resource.

引用

页码：171 / 175

页数：5

共 58 条

[1] Utah family-based analysis: Past, present and future
Albright, Lisa A. Cannon
[J]. HUMAN HEREDITY, 2008, 65 (04) : 209 - 220
[2] How well does paternity confidence match actual paternity? Evidence from worldwide nonpaternity rates
Anderson, Kermyt G.
[J]. CURRENT ANTHROPOLOGY, 2006, 47 (03) : 513 - 520
[3] [Anonymous], 2007, WORLD WIDE WEB
[4] An Expanded View of Complex Traits: From Polygenic to Omnigenic
Boyle, Evan A.
Li, Yang I.
Pritchard, Jonathan K.
[J]. CELL, 2017, 169 (07) : 1177 - 1186
[5] Cannon Albright Lisa Anne, 2006, AMIA Annu Symp Proc, P1161
[6] Cavalli-Sforza L.L., 1994, HIST GEOGRAPHY HUMAN
[7] Cavalli-Sforza LL., 2004, MG POP BIOL
[8] Chang JT, 1999, ADV APPL PROBAB, V31, P1002, DOI 10.1239/aap/1029955256
[9] Detecting gene-gene interactions that underlie human diseases
Cordell, Heather J.
[J]. NATURE REVIEWS GENETICS, 2009, 10 (06) : 392 - 404
[10] Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
Deelen, Joris
Beekman, Marian
Uh, Hae-Won
Broer, Linda
Ayers, Kristin L.
Tan, Qihua
Kamatani, Yoichiro
Bennet, Anna M.
Tamm, Riin
Trompet, Stella
Guobjartsson, Daniel F.
Flachsbart, Friederike
Rose, Giuseppina
Viktorin, Alexander
Fischer, Krista
Nygaard, Marianne
Cordell, Heather J.
Crocco, Paolina
Van den Akker, Erik B.
Bohringer, Stefan
Helmer, Quinta
Nelson, Christopher P.
Saunders, Gary I.
Alver, Maris
Andersen-Ranberg, Karen
Breen, Marie E.
van der Breggen, Ruud
Caliebe, Amke
Capri, Miriam
Cevenini, Elisa
Collerton, Joanna C.
Dato, Serena
Davies, Karen
Ford, Ian
Gampe, Jutta
Garagnani, Paolo
de Geus, Eco J. C.
Harrow, Jennifer
van Heemst, Diana
Heijmans, Bastiaan T.
Heinsen, Femke-Anouska
Hottenga, Jouke-Jan
Hofman, Albert
Jeune, Bernard
Jonsson, Palmi V.
Lathrop, Mark
Lechner, Doris
Martin-Ruiz, Carmen
Mcnerlan, Susan E.
Mihailov, Evelin
[J]. HUMAN MOLECULAR GENETICS, 2014, 23 (16) : 4420 - 4432

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