Feasibility and prospects for a vaccine to prevent cryptococcosis

被引:24
作者
Casadevall, A
Pirofski, LA
机构
[1] Albert Einstein Coll Med, Div Infect Dis, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Med, Bronx, NY USA
[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY USA
关键词
cryptococcosis; Cryptococcus neoformans; vaccine development;
D O I
10.1080/13693780500448230
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Cryptococcosis is a relatively common fungal disease caused by Cryptococcus neoformans that has high morbidity and mortality. Numerous studies have established the feasibility of enhancing host immunity to C neoformans in naive immunocompetent animal models by vaccination. Several antigens have been identified that appear to be suitable vaccine candidates. Induced immune responses can mediate protection through both humoral and cellular immunity. Hence, a vaccine against cryptococcosis in humans is probably feasible but there are significant obstacles to vaccine development that range from uncertainties about the pathogenesis of infection to economic considerations.
引用
收藏
页码:667 / 680
页数:14
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