Palladium-catalyzed enyne-yne [4+2] benzannulation as a new and general approach to polysubstituted benzenes

被引：101

作者：

Gevorgyan, V ^{[1
]}

Yamamoto, Y ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 1999年 / 576卷 / 1-2期

关键词：

enynes; diynes; alkynes; palladium; cycloaddition; benzene;

D O I：

10.1016/S0022-328X(98)01061-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Monosubstituted conjugated enynes smoothly underwent [4 + 2] homodimerization in the presence of palladium catalyst to give 4, alpha- and 2,6-disubstituted styrenes. Analogous cross-cycloaddition of conjugated enynes and diynes afforded a variety of polysubstituted benzenes, including phenol and aniline derivatives. Alkynes and diynes in the presence of a palladium catalyst underwent novel formal [2 + 2 + 2] sequential cyclotrimerization to afford multifunctional benzenes in one step with high degrees of regio- and chemoselectivities. Mechanisms of these novel transformations are discussed. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：232 / 247

页数：16

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