Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing

被引：325

作者：

Crain, D. Andrew ^{[2
]}

Janssen, Sarah J. ^{[3
]}

Edwards, Thea M. ^{[1
]}

Heindel, Jerrold ^{[4
]}

Ho, Shuk-mei ^{[5
]}

Hunt, Patricia ^{[6
]}

Iguchi, Taisen ^{[7
]}

Juul, Anders ^{[8
]}

McLachlan, John A. ^{[9
,10
]}

Schwartz, Jackie ^{[11
]}

Skakkebaek, Niels ^{[8
]}

Soto, Ana M. ^{[12
]}

Swan, Shanna ^{[13
]}

Walker, Cheryl ^{[14
]}

Woodruff, Teresa K. ^{[11
,15
]}

Woodruff, Tracey J.

Giudice, Linda C. ^{[16
]}

Guillette, Louis J., Jr. ^{[1
]}

机构：

[1] Univ Florida, Dept Zool, Gainesville, FL 32611 USA

[2] Maryville Coll, Maryville, TN USA

[3] Natl Resources Def Council, San Francisco, CA USA

[4] Natl Inst Environm Hlth Sci, Div Extramural Res & Training, Res Triangle Pk, NC USA

[5] Univ Cincinnati, Coll Med, Cincinnati, OH USA

[6] Washington State Univ, Pullman, WA 99164 USA

[7] Natl Inst Basic Biol, Natl Inst Nat Sci, Okazaki, Aichi 444, Japan

[8] Univ Dept Growth & Reprod, Rigshosp, Copenhagen, Denmark

[9] Tulane Univ, Ctr Bioenvironm Res, New Orleans, LA 70118 USA

[10] Xavier Univ, New Orleans, LA 70125 USA

[11] Univ Calif San Francisco, Program Reprod Hlth & Environm, San Francisco, CA 94143 USA

[12] Tufts Univ, Sch Med, Boston, MA 02111 USA

[13] Univ Rochester, Dept Obstet & Gynecol, Rochester, NY USA

[14] Univ Texas MD Anderson Canc Ctr, Smithville, TX USA

[15] Northwestern Univ, Dept Obstet & Gynecol, Inst Womens Hlth Res, Chicago, IL USA

[16] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA

来源：

FERTILITY AND STERILITY | 2008年 / 90卷 / 04期

关键词：

epigenetic; reproduction; endocrine disruption; aneuploidy; PCOS; cyclicity; endometriosis; leiomyoma; breast cancer; lactation; puberty;

D O I：

10.1016/j.fertnstert.2008.08.067

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health. Design: Publications related to the contribution of EDCs to disorders of the ovary (aneuploidy, polycystic ovary syndrome, and altered cyclicity), uterus (endometriosis, uterine fibroids, fetal growth restriction, and pregnancy loss), breast (breast cancer, reduced duration of lactation), and pubertal timing were identified, reviewed, and summarized at a workshop. Conclusion(S): The data reviewed illustrate that EDCs contribute to numerous human female reproductive disorders and emphasize the sensitivity of early life-stage exposures. Many research gaps are identified that limit full understanding of the contribution of EDCs to female reproductive problems. Moreover, there is an urgent need to reduce the incidence of these reproductive disorders, which can be addressed by correlative studies on early life exposure and adult reproductive dysfunction together with tools to assess the specific exposures and methods to block their effects. This review of the EDC literature as it relates to female health provides an important platform on which women's health can be improved.

引用

页码：911 / 940

页数：30

共 306 条

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