Acoustic Droplet Vaporization and Propulsion of Perfluorocarbon-Loaded Microbullets for Targeted Tissue Penetration and Deformation

被引：312

作者：

Kagan, Daniel ^{[1
]}

Benchimol, Michael J. ^{[2
]}

Claussen, Jonathan C. ^{[1
]}

Chuluun-Erdene, Erdembileg ^{[1
]}

Esener, Sadik ^{[1
]}

Wang, Joseph ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 30期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

drug delivery; electrostatic interactions; perfluorinated solvents; ultrasound; vaporization; CONTRAST AGENT; DIAGNOSTIC ULTRASOUND; CATALYTIC NANOMOTORS; BLOOD SUBSTITUTES; MICROBUBBLES; DELIVERY; DRUG; MICROENGINES; NANOMACHINES;

D O I：

10.1002/anie.201201902

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bullets and rockets: Ultrasound-triggered vaporization of a perfluorocarbon compound loaded into microbullets provides the necessary force for the microbullets to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery. The microbullets have an inner Au layer that allows conjugation of a monolayer of thiolated cysteamine (green in picture) for electrostatic attachment of perfluorocarbon droplets (purple droplets). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7519 / 7522

页数：4

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