Inhibitory ITAMs: a matter of life and death

被引：49

作者：

da Silva, Fabiano Pinheiro ^{[1
,2
,3
]}

Aloulou, Meryern ^{[1
,2
]}

Benhamou, Marc ^{[1
,2
]}

Monteiro, Renato C. ^{[1
,2
]}

机构：

[1] Univ Paris 07, INSERM, U699, F-75018 Paris, France

[2] Univ Paris 07, Bichat Med Sch, F-75018 Paris, France

[3] Univ Sao Paulo, Dept Emergency Med, BR-01246903 Sao Paulo, Brazil

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 08期

关键词：

D O I：

10.1016/j.it.2008.05.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The balance between activating and inhibitory signals is essential to control immune responses to microorganisms. Innate and adaptive immune responses are regulated by receptors that signal through either an immunoreceptor tyrosine-based activation motif (ITAM) or an immunoreceptor tyrosine-based inhibitory motif (ITIM). When clustered, these motifs are, respectively, responsible for activating and inhibitory signals. Recently, the concept of inhibitory ITAM (ITAM(i)) has emerged as a new means to negatively control the immune response. In this Opinion, we will discuss the ability of Escherichia coli to evade the immune system by eliciting ITAM(i) function through Fc gamma RIII (CD16) on phagocytes leading to uncontrolled systemic infection and sepsis. Elucidating such mechanisms will open opportunities for specific therapeutic manipulation of ITAM(i)-based signaling pathways.

引用

页码：366 / 373

页数：8

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