The Reactome Pathway Knowledgebase

被引：1906

作者：

Fabregat, Antonio ^{[1
,2
]}

Jupe, Steven ^{[1
]}

Matthews, Lisa ^{[3
]}

Sidiropoulos, Konstantinos ^{[1
]}

Gillespie, Marc ^{[4
,5
]}

Garapati, Phani ^{[1
]}

Haw, Robin ^{[4
]}

Jassal, Bijay ^{[4
]}

Korninger, Florian ^{[1
]}

May, Bruce ^{[4
]}

Milacic, Marija ^{[4
]}

Roca, Corina Duenas ^{[1
]}

Rothfels, Karen ^{[4
]}

Sevilla, Cristoffer ^{[1
]}

Shamovsky, Veronica ^{[3
]}

Shorser, Solomon ^{[4
]}

Varusai, Thawfeek ^{[1
]}

Viteri, Guilherme ^{[1
]}

Weiser, Joel ^{[4
]}

Wu, Guanming ^{[6
]}

Stein, Lincoln ^{[4
,7
]}

Hermjakob, Henning ^{[1
,8
]}

D'Eustachio, Peter ^{[3
]}

机构：

[1] EBI, EMBL, Wellcome Genome Campus, Hinxton CB10 1SD, Cambs, England

[2] Open Targets, Wellcome Genome Campus, Hinxton CB10 1SD, Cambs, England

[3] NYU, Sch Med, New York, NY 10016 USA

[4] Ontario Inst Canc Res, Toronto, ON M5G 0A3, Canada

[5] St Johns Univ, Coll Pharm & Hlth Sci, Queens, NY 11439 USA

[6] Oregon Hlth & Sci Univ, Portland, OR 97239 USA

[7] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada

[8] Natl Ctr Prot Sci, Beijing, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2018年 / 46卷 / D1期

基金：

美国国家卫生研究院;

关键词：

ONTOLOGY; DATABASE;

D O I：

10.1093/nar/gkx1132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Reactome Knowledgebase (https://reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism, and other cellular processes as an ordered network of molecular transformations-an extended version of a classic metabolic map, in a single consistent data model. Reactome functions both as an archive of biological processes and as a tool for discovering unexpected functional relationships in data such as gene expression profiles or somatic mutation catalogues from tumor cells. To support the continued brisk growth in the size and complexity of Reactome, we have implemented a graph database, improved performance of data analysis tools, and designed new data structures and strategies to boost diagram viewer performance. To make our website more accessible to human users, we have improved pathway display and navigation by implementing interactive Enhanced High Level Diagrams (EHLDs) with an associated icon library, and subpathway highlighting and zooming, in a simplified and reorganized web site with adaptive design. To encourage re-use of our content, we have enabled export of pathway diagrams as 'PowerPoint' files.

引用

页码：D649 / D655

页数：7

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