Keeping active endogenous retroviral-like elements in check: the epigenetic perspective

被引：131

作者：

Maksakova, I. A.

Mager, D. L. ^{[1
]}

Reiss, D.

机构：

[1] British Columbia Canc Res Ctr, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 21期

基金：

加拿大健康研究院;

关键词：

LTR retrotransposon; epigenetics; DNA methylation; chromatin; mouse development; retroviral silencing; RNAi;

D O I：

10.1007/s00018-008-8494-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endogenous retrovirus-like elements, or ERVs, are an abundant component of all eukaryotic genomes. Their transcriptional and retrotranspositional activities have great potential for deleterious effects on gene expression. Consequences of such activity may include germline mutagenesis and cancerous transformation. As a result, mammalian genomes have evolved means of counteracting ERV transcription and mobilization. In this review, we discuss epigenetic mechanisms of ERV and LTR retrotransposon control during mouse development, focusing on involvement of DNA methylation, histone modifications, small RNAs and their interaction with one another. We also address relevance of research performed in the mouse system to human and challenges associated with studying repetitive families. (Part of a Multi-author Review).

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页码：3329 / 3347

页数：19

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