Strategies for improving the repair of focal cartilage defects

被引：29

作者：

Abdel-Sayed, Philippe ^{[1
]}

Pioletti, Dominique P. ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Biomech Orthoped, Inst Bioengn, CH-1015 Lausanne, Switzerland

来源：

NANOMEDICINE | 2015年 / 10卷 / 18期

关键词：

ACI; AMIC; cartilage repair; hydrogel; MACI; microfracture; repair; scaffold; AUTOLOGOUS CHONDROCYTE IMPLANTATION; MESENCHYMAL STEM-CELLS; FIBRIN-POLYURETHANE COMPOSITES; MARROW STROMAL CELLS; TISSUE ENGINEERING APPLICATIONS; TERM-FOLLOW-UP; ARTICULAR-CARTILAGE; IN-VITRO; DYNAMIC COMPRESSION; CHONDROITIN SULFATE;

D O I：

10.2217/nnm.15.119

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Articular cartilage, together with skin, was predicted to be one of the first tissues to be successfully engineered. However cartilage repair remains nowadays still elusive, as we are still not able to overcome the hurdles of creating biomaterials corresponding to the native properties of the tissue, and which operate in joints environment that is not favorable for regeneration. In this review, we give an overview of the outcome of current cartilage treatment techniques. Furthermore we present current research strategies for improving cartilage tissue engineering.

引用

页码：2893 / 2905

页数：13

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