A New Efficient Catalytic System for the Chemoselective Cobalt-Catalyzed Cross-Coupling of Aryl Grignard Reagents with Primary and Secondary Alkyl Bromides

被引：83

作者：

Cahiez, Gerard ^{[1
]}

Chaboche, Christophe ^{[1
]}

Duplais, Christophe ^{[1
]}

Moyeux, Alban ^{[1
]}

机构：

[1] Univ Paris 13, CNRS, Dept Chem, F-93017 Bobigny, France

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 02期

关键词：

BEARING BETA-HYDROGENS; CARBON BOND FORMATION; HETEROCYCLIC CHLORIDES; HALIDES; ALKENYLATION;

D O I：

10.1021/ol802362e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cobalt-catalyzed alkylation of aromatic Grignard reagents is performed in good yields by using a new simple and efficient catalytic system: CoCl(2)/TMEDA (1:1). Primary and secondary cyclic or acyclic alkyl bromides were used successfully. The reaction is highly chemoselective since ester, amide, and keto groups are tolerated. The procedure is inexpensive and very easy to carry out on a larger scale.

引用

页码：277 / 280

页数：4

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