RORγt+ Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Receptor NKp44

被引：166

作者：

Glatzer, Timor ^{[1
]}

Killig, Monica ^{[1
]}

Meisig, Johannes ^{[2
,7
]}

Ommert, Isabelle ^{[1
]}

Luetke-Eversloh, Merlin ^{[1
]}

Babic, Marina ^{[1
,8
]}

Paclik, Daniela ^{[1
]}

Bluethgen, Nils ^{[2
,7
]}

Seidl, Rainer ^{[9
]}

Seifarth, Claudia ^{[3
,4
]}

Groene, Joern ^{[3
,4
]}

Lenarz, Minoo ^{[5
]}

Stoelzel, Katharina ^{[5
]}

Fugmann, Dominik ^{[6
]}

Porgador, Angel ^{[10
,11
]}

Hauser, Anja ^{[1
]}

Karlas, Alexander ^{[12
]}

Romagnani, Chiara ^{[1
]}

机构：

[1] Deutsch Rheumaforsch Zentrum Leibniz Gemeinschaft, D-10117 Berlin, Germany

[2] Charite, Inst Pathol, D-12200 Berlin, Germany

[3] Charite, Chirurg Klin, D-12200 Berlin, Germany

[4] Charite, Hsch Ambulanz 1, D-12200 Berlin, Germany

[5] Charite, HNO Klin, D-12200 Berlin, Germany

[6] Charite, Klin Allgemein Visceral & Transplantat Chirurg, D-12200 Berlin, Germany

[7] Humboldt Univ, Inst Theoret Biol, D-10115 Berlin, Germany

[8] Univ Rijeka, Fac Med, Dept Histol & Embryol, Rijeka RIJEKA, Croatia

[9] Unfallkrankenhaus, HNO Klin, D-12683 Berlin, Germany

[10] Ben Gurion Univ Negev, Shraga Segal Dept Microbiol & Immunol, IL-84105 Beer Sheva, Israel

[11] Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, IL-84105 Beer Sheva, Israel

[12] Max Planck Inst Infect Biol, Dept Mol Biol, D-10117 Berlin, Germany

来源：

IMMUNITY | 2013年 / 38卷 / 06期

关键词：

ROR-GAMMA-T; NK CELLS; EXPRESSION; HEMAGGLUTININS; RECOGNITION; LIGANDS; DRIVES; FAMILY; NKP30; GUT;

D O I：

10.1016/j.immuni.2013.05.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

ROR gamma t(+) innate lymphoid cells (ILCs) are crucial players of innate immune responses and represent a major source of interleukin-22 (IL-22), which has an important role in mucosal homeostasis. The signals required by ROR gamma t(+) ILCs to express IL-22 and other cytokines have been elucidated only partially. Here we showed that ROR gamma t(+) ILCs can directly sense the environment by the engagement of the activating receptor NKp44. NKp44 triggering in ROR gamma t(+) ILCs selectively activated a coordinated proinflammatory program, including tumor necrosis factor (TNF), whereas cytokine stimulation preferentially induced IL-22 expression. However, combined engagement of NKp44 and cytokine receptors resulted in a strong synergistic effect. These data support the concept that NKp44(+) ROR gamma t(+) ILCs can be activated without cytokines and are able to switch between IL-22 or TNF production, dependingon the triggering stimulus.

引用

页码：1223 / 1235

页数：13

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