The Morita-Baylis-Hillman adducts of β-aryl nitroethylenes with other activated alkenes:: synthesis and anticancer activity studies

被引：72

作者：

Dadwal, M

Mohan, R

Panda, D ^{[1
]}

Mobin, SM

Namboothiri, INN

机构：

[1] Indian Inst Technol, Sch Biosci & Bioengn, Bombay 400076, Maharashtra, India

[2] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

[3] Indian Inst Technol, Natl Single Crystal Xray Diffract Facil, Bombay 400076, Maharashtra, India

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 03期

关键词：

D O I：

10.1039/b512267h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Morita-Baylis-Hillman (MBH) adducts of beta-aryl nitroethylenes with methyl vinyl ketone (MVK) and acrylate, formed in moderate to good yield when mediated by imidazole/LiCl in THF at room temperature, inhibit HeLa cell prolifieration by binding to tubulin.

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页码：338 / 340

页数：3

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