Salmonella entry into host cells:: the work in concert of type III secreted effector proteins

被引：238

作者：

Zhou, DG ^{[1
]}

Galán, J

机构：

[1] Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA

[2] Yale Univ, Sch Nursing, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 14-15期

关键词：

actin cytoskeleton; bacterial pathogenesis; Salmonella; signal transduction; type III secretion;

D O I：

10.1016/S1286-4579(01)01489-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Upon contact with intestinal epithelial cells, Salmonella enterica serovar spp. inject a set of bacterial proteins into host cells via the bacterial SPI-1 type III secretion system. SopE, SopE2 and SopB, activate CDC42 and Rac to initiate actin cytoskeleton rearrangements, SipA and SipC, two Salmonella actin-binding proteins, directly modulate host actin dynamics to facilitate bacterial uptake. SptP promotes the recovery of the actin cytoskeleton rearrangements by antagonizing CDC42 and Rac. Therefore, Salmonella-induced reversible actin cytoskeleton rearrangements are the result of two coordinated steps: (i) stimulation of host signal transduction to indirectly promote actin rearrangements and (ii) direct modulation of actin dynamics. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：1293 / 1298

页数：6

共 59 条

[1] Identification of SopE2, a Salmonella secreted protein which is highly homologous to SopE and involved in bacterial invasion of epithelial cells [J].