A new, one pot synthesis of alkylated methyl tri- and tetracarboxylate derivatives by nitroalkanes

被引：12

作者：

Ballini, R ^{[1
]}

Bosica, G ^{[1
]}

Fiorini, D ^{[1
]}

Gil, MV ^{[1
]}

Palmieri, A ^{[1
]}

机构：

[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy

来源：

SYNTHESIS-STUTTGART | 2004年 / 04期

关键词：

nitroalkanes; dimethyl maleate; methyl trialkanoate; methyl tetraalkanoate; triols;

D O I：

10.1055/s-2004-815948

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of nitroalkanes with trimethyl trans-aconitate in acetonitrile, in the presence of DBU as base, allows the one pot formation of alkylated methyl tri- and tetralkanoate derivatives via base induced nitrous acid elimination. The title compounds can also be obtained, in one flask, starting with the reaction of methyl nitroacetate with dimethyl maleate, followed by the addition, in the same flask of the nitroalkane.

引用

收藏

页码：605 / 609

页数：5

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