Enantioselective oxidation of (RS)-2-phenyl-1-propanol to (S)-2-phenylpropanoic acid with Gluconobacter oxydans:: simplex optimization of the biotransformation

被引:34
作者
Molinari, F
Villa, R
Aragozzini, F
Leon, R
Prazeres, DMF
机构
[1] Univ Milan, Dipartimento Sci & Tecnol Alimentari & Microbiol, Sez Microbiol Ind, I-20133 Milan, Italy
[2] Inst Super Tecn, Ctr Engn Biol & Quim, P-1000 Lisbon, Portugal
关键词
D O I
10.1016/S0957-4166(99)00309-2
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The microbial oxidation of racemic 2-phenyl-1-propanol by Gluconobacter oxydans DSM 50049 was investigated. Whole bacterial cells were used to produce (S)-(+)-2-phenylpropanoic acid with high enantiomeric excess (E>200). A simplex sequential method was employed as an experimental design to guide the optimization process. Temperature of 26-28 degrees C, pH 6.0-6.2, substrate concentration of 20-25 mM and agitation of 150 rpm have been found the best conditions to achieve the highest reaction rates and enantioselectivities. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码:3003 / 3009
页数:7
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