Manzamine C congeners with modified azacyclic rings: Synthesis and biological evaluation

被引：11

作者：

Torisawa, Y

Hashimoto, A

Okouchi, M

Iimori, T

Nagasawa, M

Hino, T

Nakagawa, M

机构：

[1] CHIBA UNIV,FAC PHARMACEUT SCI,INAGE KU,CHIBA 263,JAPAN

[2] TEIKYO UNIV,FAC PHARMACEUT SCI,KANAGAWA 19901,JAPAN

[3] MEIJI SEIKA KAISHA LTD,PHARMACEUT RES CTR,KOHOKU KU,YOKOHAMA,KANAGAWA 222,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 21期

关键词：

D O I：

10.1016/0960-894X(96)00460-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Manzamine C congeners with modified azacyclic rings were synthesized using a DPPA-promoted conjunction of the beta-carboline-1-acetate salt with various amines as a key reaction. A preliminary biological evaluation revealed that these analogues retained similar activities as Manzamine C. Copyright (C) 1996 Elsevier Science Ltd

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页码：2565 / 2570

页数：6

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