Therapeutic Angiogenesis for Treating Cardiovascular Diseases

被引：152

作者：

Deveza, Lorenzo ^{[1
]}

Choi, Jeffrey ^{[2
]}

Yang, Fan ^{[1
,3
]}

机构：

[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA

来源：

THERANOSTICS | 2012年 / 2卷 / 08期

关键词：

Angiogenesis; Cardiovascular Diseases; ENDOTHELIAL GROWTH-FACTOR; ACUTE MYOCARDIAL-INFARCTION; IMPROVES CARDIAC-FUNCTION; HINDLIMB ISCHEMIA MODEL; STEM-CELL THERAPY; BONE-MARROW; PROGENITOR CELLS; G-CSF; VASCULAR REGENERATION; CONTROLLED-RELEASE;

D O I：

10.7150/thno.4419

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Cardiovascular disease is the leading cause of death worldwide and is often associated with partial or full occlusion of the blood vessel network in the affected organs. Restoring blood supply is critical for the successful treatment of cardiovascular diseases. Therapeutic angiogenesis provides a valuable tool for treating cardiovascular diseases by stimulating the growth of new blood vessels from pre-existing vessels. In this review, we discuss strategies developed for therapeutic angiogenesis using single or combinations of biological signals, cells and polymeric biomaterials. Compared to direct delivery of growth factors or cells alone, polymeric biomaterials provide a three-dimensional drug-releasing depot that is capable of facilitating temporally and spatially controlled release. Biomimetic signals can also be incorporated into polymeric scaffolds to allow environmentally-responsive or cell-triggered release of biological signals for targeted angiogenesis. Recent progress in exploiting genetically engineered stem cells and endogenous cell homing mechanisms for therapeutic angiogenesis is also discussed.

引用

页码：801 / 814

页数：14

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