Tumor suppression in triploid trout

被引：9

作者：

Thorgaard, GH ^{[1
]}

Arbogast, DN

Hendricks, JD

Pereira, CB

Bailey, GS

机构：

[1] Washington State Univ, Dept Zool, Pullman, WA 99164 USA

[2] Washington State Univ, Dept Genet & Cell Biol, Pullman, WA 99164 USA

[3] Oregon State Univ, Dept Food Sci & Technol, Corvallis, OR 97331 USA

[4] Oregon State Univ, Dept Stat, Corvallis, OR 97331 USA

[5] Oregon State Univ, Marine Freshwater Biomed Sci Ctr, Corvallis, OR 97331 USA

来源：

AQUATIC TOXICOLOGY | 1999年 / 46卷 / 02期

基金：

美国国家卫生研究院;

关键词：

cancer; tumor; triploid; trout; Oncorhynchus mykiss;

D O I：

10.1016/S0166-445X(98)00121-0

中图分类号：

Q17 [水生生物学];

学科分类号：

071004 ;

摘要：

Triploidy was induced in rainbow trout (Oncorhynchus mykiss) by heat shock of fertilized eggs and triploid and diploid fry were treated with three carcinogens (DMBA, MNNG and aflatoxin B1) by bath exposure. The incidence of tumors was substantially lower in triploids than in diploids in the swimbladder, stomach and kidney and moderately lower in the liver. The lower tumor incidence in triploids may reflect a lower likelihood that all copies of tumor suppressor genes would mutate during carcinogenesis in triploids. Polyploid lower vertebrates may thus provide novel systems for investigating tumor suppressor genes in carcinogenesis. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：121 / 126

页数：6

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