Metabotropic G-protein-coupled glutamate receptors as therapeutic targets

被引：67

作者：

Pellicciari, R ^{[1
]}

Costantino, G ^{[1
]}

机构：

[1] Ist Chim & Tecnol Farm, I-06123 Perugia, Italy

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(99)80064-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabotropic glutamate receptors have received considerable attention over the past decade in view of their relevance in multiple aspects of glutamatergic transmission. Recent advances in the molecular biology, pharmacology and medicinal chemistry of this family of G-protein-coupled receptors have led to therapeutic opportunities for subtype-selective modulators in brain disorders and diseases such as: ischemia and schizophrenia.

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页码：433 / 440

页数：8

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