Biomaterial implants induce the inflammation marker CRP at the site of implantation

被引：28

作者：

Löbler, M

Sass, M

Kunze, C

Schmitz, KP

Hopt, UT

机构：

[1] Univ Freiburg, Chirurg Univ Klin, D-79106 Freiburg, Germany

[2] Univ Rostock, Klin & Poliklin Chirurg, D-18057 Rostock, Germany

[3] Kompetenzzentrum Biomat, Inst Biomed Techn, D-18057 Rostock, Germany

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 2002年 / 61卷 / 01期

关键词：

biomaterial; implant; Vicryl; PHB; soft tissue; response; mRNA differential display;

D O I：

10.1002/jbm.10155

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Following implantation of biomaterial patches into the gastrointestinal tract, we analyzed the host's response towards the foreign material. Asymmetric patches of polydioxanone covered Vicryl or poly-3-hydroxybutyrate were sutured onto the rat stomach. Tissue samples were generated at distinct time intervals after surgery, and RNA profiles were compared by Differential Display. RT-PCR analysis of gene candidates that seemed differentially expressed showed that vitamin D binding protein mRNA was induced in stomach tissue after implantation of the biomaterial patches. In parallel, the amount of C-reactive protein mRNA was found to be increased transiently as well. Implants induce a tissue response that is specific for a given material. © 2002 Wiley Periodicals, Inc.

引用

页码：165 / 167

页数：3

共 8 条

[1] Neutrophil priming by cytokines and vitamin D binding protein (Gc-globulin): impact on C5a-mediated chemotaxis, degranulation and respiratory burst [J].