New technique for high-throughput synthesis

被引：22

作者：

Lebl, M ^{[1
]}

机构：

[1] Spyder Instruments Inc, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(99)00176-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new technique for high throughput solid phase synthesis using the centrifuge based liquid removal from readily available standard microtiterplates is described. This technique eliminates the filtration step and is therefore applicable to simultaneous processing of an unlimited number of reaction compartments. Its application is illustrated on the synthesis of an array of 380 tetrahydroisoquinolinones. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1305 / 1310

页数：6

共 8 条

[1] New methods in combinatorial chemistry - robotics and parallel synthesis [J].