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The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks
被引:61
作者:

Courilleau, Celine
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Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France
Univ Toulouse 3, Ctr Natl Rech Sci, F-31062 Toulouse, France Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France

Chailleux, Catherine
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Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France
Univ Toulouse 3, Ctr Natl Rech Sci, F-31062 Toulouse, France Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France

Jauneau, Alain
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Ctr Natl Rech Sci, Plateforme Microscopie Imagerie FR3450, F-31326 Castanet Tolosan, France Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France

Grimal, Fanny
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Univ Toulouse, Ctr Rech Cancerol Toulouse, UMR 1037, Inst Natl Sante & Rech Med, F-31024 Toulouse, France Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France

Briois, Sebastien
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Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France
Univ Toulouse 3, Ctr Natl Rech Sci, F-31062 Toulouse, France Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France

Boutet-Robinet, Elisa
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机构:
Inst Natl Rech Agron, Res Ctr Food Toxicol, UMR 1131, F-31027 Toulouse, France
Univ Toulouse, F-31027 Toulouse, France Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France

Boudsocq, Francois
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Univ Toulouse, Lab Biol Mol Eucaryote, UMR 5099, Ctr Natl Rech Sci, F-31062 Toulouse, France Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France

Trouche, Didier
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Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France
Univ Toulouse 3, Ctr Natl Rech Sci, F-31062 Toulouse, France Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France

Canitrot, Yvan
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h-index: 0
机构:
Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France
Univ Toulouse 3, Ctr Natl Rech Sci, F-31062 Toulouse, France Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France
机构:
[1] Univ Toulouse, Lab Biol Cellulaire & Mol Controle Proliferat, UMR 5088, F-31062 Toulouse, France
[2] Univ Toulouse 3, Ctr Natl Rech Sci, F-31062 Toulouse, France
[3] Ctr Natl Rech Sci, Plateforme Microscopie Imagerie FR3450, F-31326 Castanet Tolosan, France
[4] Univ Toulouse, Ctr Rech Cancerol Toulouse, UMR 1037, Inst Natl Sante & Rech Med, F-31024 Toulouse, France
[5] Inst Natl Rech Agron, Res Ctr Food Toxicol, UMR 1131, F-31027 Toulouse, France
[6] Univ Toulouse, F-31027 Toulouse, France
[7] Univ Toulouse, Lab Biol Mol Eucaryote, UMR 5099, Ctr Natl Rech Sci, F-31062 Toulouse, France
关键词:
HOMOLOGOUS RECOMBINATION;
DISTINCT ROLES;
HUMAN-CELLS;
IN-VIVO;
DAMAGE;
COMPLEX;
ACETYLATION;
TIP60;
INO80;
APOPTOSIS;
D O I:
10.1083/jcb.201205059
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
DNA damage signaling and repair take place in a chromatin context. Consequently, chromatin-modifying enzymes, including adenosine triphosphate dependent chromatin remodeling enzymes, play an important role in the management of DNA double-strand breaks (DSBs). Here, we show that the p400 ATPase is required for DNA repair by homologous recombination (HR). Indeed, although p400 is not required for DNA damage signaling, DNA DSB repair is defective in the absence of p400. We demonstrate that p400 is important for HR-dependent processes, such as recruitment of Rad51 to DSB (a key component of HR), homology-directed repair, and survival after DNA damage. Strikingly, p400 and Rad51 are present in the same complex and both favor chromatin remodeling around DSBs. Altogether, our data provide a direct molecular link between Rad51 and a chromatin remodeling enzyme involved in chromatin decompaction around DNA DSBs.
引用
收藏
页码:1067 / 1081
页数:15
相关论文
共 57 条
[11]
Bax and Bid, two proapoptotic Bcl-2 family members, inhibit homologous recombination, independently of apoptosis regulation
[J].
Dumay, A.
;
Laulier, C.
;
Bertrand, P.
;
Saintigny, Y.
;
Lebrun, F.
;
Vayssiére, J-L
;
Lopez, B. S.
.
ONCOGENE,
2006, 25 (22)
:3196-3205

Dumay, A.
论文数: 0 引用数: 0
h-index: 0
机构: CEA, CNRS, UMR 217, DSV,DRR, F-92265 Fontenay Aux Roses, France

Laulier, C.
论文数: 0 引用数: 0
h-index: 0
机构: CEA, CNRS, UMR 217, DSV,DRR, F-92265 Fontenay Aux Roses, France

Bertrand, P.
论文数: 0 引用数: 0
h-index: 0
机构: CEA, CNRS, UMR 217, DSV,DRR, F-92265 Fontenay Aux Roses, France

Saintigny, Y.
论文数: 0 引用数: 0
h-index: 0
机构: CEA, CNRS, UMR 217, DSV,DRR, F-92265 Fontenay Aux Roses, France

Lebrun, F.
论文数: 0 引用数: 0
h-index: 0
机构: CEA, CNRS, UMR 217, DSV,DRR, F-92265 Fontenay Aux Roses, France

Vayssiére, J-L
论文数: 0 引用数: 0
h-index: 0
机构: CEA, CNRS, UMR 217, DSV,DRR, F-92265 Fontenay Aux Roses, France

Lopez, B. S.
论文数: 0 引用数: 0
h-index: 0
机构: CEA, CNRS, UMR 217, DSV,DRR, F-92265 Fontenay Aux Roses, France
[12]
The p400 complex is an essential E1A transformation target
[J].
Fuchs, M
;
Gerber, J
;
Drapkin, R
;
Sif, S
;
Ikura, T
;
Ogryzko, V
;
Lane, WS
;
Nakatani, Y
;
Livingston, DM
.
CELL,
2001, 106 (03)
:297-307

Fuchs, M
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Sif, S
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Ikura, T
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Ogryzko, V
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Lane, WS
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Nakatani, Y
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Livingston, DM
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Boston, MA 02115 USA Dana Farber Canc Inst, Boston, MA 02115 USA
[13]
p21 transcription is regulated by differential localization of histone H2A.Z
[J].
Gevry, Nicolas
;
Chan, Ho Man
;
Laflamme, Liette
;
Livingston, David M.
;
Gaudreau, Luc
.
GENES & DEVELOPMENT,
2007, 21 (15)
:1869-1881

Gevry, Nicolas
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sherbrooke, Fac Sci, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada

Chan, Ho Man
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sherbrooke, Fac Sci, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada

Laflamme, Liette
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sherbrooke, Fac Sci, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada

Livingston, David M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sherbrooke, Fac Sci, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada Univ Sherbrooke, Fac Sci, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada

Gaudreau, Luc
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sherbrooke, Fac Sci, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada
[14]
Interaction of human recombination proteins Rad51 and Rad54
[J].
Golub, EI
;
Kovalenko, OV
;
Gupta, RC
;
Ward, DC
;
Radding, CM
.
NUCLEIC ACIDS RESEARCH,
1997, 25 (20)
:4106-4110

Golub, EI
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA

Kovalenko, OV
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA

Gupta, RC
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA

Ward, DC
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA

Radding, CM
论文数: 0 引用数: 0
h-index: 0
机构:
YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA YALE UNIV, SCH MED, DEPT MOL BIOPHYS & BIOCHEM, NEW HAVEN, CT 06510 USA
[15]
Mammalian Ino80 Mediates Double-Strand Break Repair through Its Role in DNA End Strand Resection
[J].
Gospodinov, Anastas
;
Vaissiere, Thomas
;
Krastev, Dragomir B.
;
Legube, Gaelle
;
Anachkova, Boyka
;
Herceg, Zdenko
.
MOLECULAR AND CELLULAR BIOLOGY,
2011, 31 (23)
:4735-4745

论文数: 引用数:
h-index:
机构:

Vaissiere, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Int Agcy Res Canc, Epigenet Grp, F-69372 Lyon 08, France Int Agcy Res Canc, Epigenet Grp, F-69372 Lyon 08, France

Krastev, Dragomir B.
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany Int Agcy Res Canc, Epigenet Grp, F-69372 Lyon 08, France

Legube, Gaelle
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, LBCMCP, F-31062 Toulouse, France
Univ Toulouse, F-31062 Toulouse, France Int Agcy Res Canc, Epigenet Grp, F-69372 Lyon 08, France

Anachkova, Boyka
论文数: 0 引用数: 0
h-index: 0
机构:
Bulgarian Acad Sci, Inst Mol Biol, BU-1113 Sofia, Bulgaria Int Agcy Res Canc, Epigenet Grp, F-69372 Lyon 08, France

Herceg, Zdenko
论文数: 0 引用数: 0
h-index: 0
机构:
Int Agcy Res Canc, Epigenet Grp, F-69372 Lyon 08, France Int Agcy Res Canc, Epigenet Grp, F-69372 Lyon 08, France
[16]
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler
[J].
Gottschalk, Aaron J.
;
Timinszky, Gyula
;
Kong, Stephanie E.
;
Jin, Jingji
;
Cai, Yong
;
Swanson, Selene K.
;
Washburn, Michael P.
;
Florens, Laurence
;
Ladurner, Andreas G.
;
Conaway, Joan W.
;
Conaway, Ronald C.
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2009, 106 (33)
:13770-13774

Gottschalk, Aaron J.
论文数: 0 引用数: 0
h-index: 0
机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA
Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany

Timinszky, Gyula
论文数: 0 引用数: 0
h-index: 0
机构:
European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany

Kong, Stephanie E.
论文数: 0 引用数: 0
h-index: 0
机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany

Jin, Jingji
论文数: 0 引用数: 0
h-index: 0
机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany

Cai, Yong
论文数: 0 引用数: 0
h-index: 0
机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany

Swanson, Selene K.
论文数: 0 引用数: 0
h-index: 0
机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany

Washburn, Michael P.
论文数: 0 引用数: 0
h-index: 0
机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany

Florens, Laurence
论文数: 0 引用数: 0
h-index: 0
机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany

Ladurner, Andreas G.
论文数: 0 引用数: 0
h-index: 0
机构:
European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany
European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany

Conaway, Joan W.
论文数: 0 引用数: 0
h-index: 0
机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA
Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany

Conaway, Ronald C.
论文数: 0 引用数: 0
h-index: 0
机构:
Stowers Inst Med Res, Kansas City, MO 64110 USA
Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA European Mol Biol Lab, Gene Express Unit, D-69117 Heidelberg, Germany
[17]
NUCLEAR FOCI OF MAMMALIAN RAD51 RECOMBINATION PROTEIN IN SOMATIC-CELLS AFTER DNA-DAMAGE AND ITS LOCALIZATION IN SYNAPTONEMAL COMPLEXES
[J].
HAAF, T
;
GOLUB, EI
;
REDDY, G
;
RADDING, CM
;
WARD, DC
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1995, 92 (06)
:2298-2302

HAAF, T
论文数: 0 引用数: 0
h-index: 0
机构: Department of Genetics, Yale University, School of Medicine, New Haven, CT 06510

GOLUB, EI
论文数: 0 引用数: 0
h-index: 0
机构: Department of Genetics, Yale University, School of Medicine, New Haven, CT 06510

REDDY, G
论文数: 0 引用数: 0
h-index: 0
机构: Department of Genetics, Yale University, School of Medicine, New Haven, CT 06510

RADDING, CM
论文数: 0 引用数: 0
h-index: 0
机构: Department of Genetics, Yale University, School of Medicine, New Haven, CT 06510

WARD, DC
论文数: 0 引用数: 0
h-index: 0
机构: Department of Genetics, Yale University, School of Medicine, New Haven, CT 06510
[18]
Genome maintenance mechanisms for preventing cancer
[J].
Hoeijmakers, JHJ
.
NATURE,
2001, 411 (6835)
:366-374

Hoeijmakers, JHJ
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus Univ, Ctr Biomed Genet, MGC Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands Erasmus Univ, Ctr Biomed Genet, MGC Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands
[19]
High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome
[J].
Iacovoni, Jason S.
;
Caron, Pierre
;
Lassadi, Imen
;
Nicolas, Estelle
;
Massip, Laurent
;
Trouche, Didier
;
Legube, Gaelle
.
EMBO JOURNAL,
2010, 29 (08)
:1446-1457

Iacovoni, Jason S.
论文数: 0 引用数: 0
h-index: 0
机构:
Fac Med Toulouse, INSERM, Bioinformat Plateau IFR150, F-31073 Toulouse, France
Univ Toulouse, F-31062 Toulouse, France CNRS, LBCMCP, UMR5088, F-31062 Toulouse, France

论文数: 引用数:
h-index:
机构:

Lassadi, Imen
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, LBME, F-31062 Toulouse, France
Univ Toulouse, F-31062 Toulouse, France CNRS, LBCMCP, UMR5088, F-31062 Toulouse, France

Nicolas, Estelle
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, LBCMCP, UMR5088, F-31062 Toulouse, France
Univ Toulouse, F-31062 Toulouse, France CNRS, LBCMCP, UMR5088, F-31062 Toulouse, France

Massip, Laurent
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, LBCMCP, UMR5088, F-31062 Toulouse, France
Univ Toulouse, F-31062 Toulouse, France CNRS, LBCMCP, UMR5088, F-31062 Toulouse, France

Trouche, Didier
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, LBCMCP, UMR5088, F-31062 Toulouse, France
Univ Toulouse, F-31062 Toulouse, France CNRS, LBCMCP, UMR5088, F-31062 Toulouse, France

Legube, Gaelle
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, LBCMCP, UMR5088, F-31062 Toulouse, France
Univ Toulouse, F-31062 Toulouse, France CNRS, LBCMCP, UMR5088, F-31062 Toulouse, France
[20]
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
[J].
Ikura, T
;
Ogryzko, VV
;
Grigoriev, M
;
Groisman, R
;
Wang, J
;
Horikoshi, M
;
Scully, R
;
Qin, J
;
Nakatani, Y
.
CELL,
2000, 102 (04)
:463-473

Ikura, T
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Ogryzko, VV
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Grigoriev, M
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

论文数: 引用数:
h-index:
机构:

Wang, J
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Horikoshi, M
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Scully, R
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Qin, J
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Boston, MA 02115 USA

Nakatani, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Boston, MA 02115 USA Dana Farber Canc Inst, Boston, MA 02115 USA