Initiation of pre-B cell receptor signaling: Common and distinctive features in human and mouse

被引:32
作者
Espeli, M
Rossi, B
Mancini, SJC
Roche, P
Gauthier, L
Schiff, C
机构
[1] Univ Mediterranee, INSERM, CNRS, CIML, F-13288 Marseille 09, France
[2] Inst Biol Struct & Microbiol, F-130402 Marseille, France
基金
澳大利亚研究理事会;
关键词
pre-BCR; bone marrow; stroma; galectin; heparan sulfate;
D O I
10.1016/j.smim.2005.11.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
B cell development in the bone marrow is a highly regulated process and expression of a functional pre-BCR represents a crucial checkpoint, common to human and Muse. In this review, we discuss pre-BCR analogies and differences between the two species leading to pre-B cell differentiation and proliferation. In addition. the mechanisms triggering pre-BCR activation are reviewed, taking into account the recent report of heparan sulfates and plectin 1 as stromal cell-derived pre-BCR ligands. Finally, ligand-induced pre-BCR activation models are proposed oil the bases of the differences reported for pre-BCR and IL7 dependencies in the two species. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:56 / 66
页数:11
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