Initiation of pre-B cell receptor signaling: Common and distinctive features in human and mouse

被引：32

作者：

Espeli, M

Rossi, B

Mancini, SJC

Roche, P

Gauthier, L

Schiff, C

机构：

[1] Univ Mediterranee, INSERM, CNRS, CIML, F-13288 Marseille 09, France

[2] Inst Biol Struct & Microbiol, F-130402 Marseille, France

来源：

SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 01期

基金：

澳大利亚研究理事会;

关键词：

pre-BCR; bone marrow; stroma; galectin; heparan sulfate;

D O I：

10.1016/j.smim.2005.11.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cell development in the bone marrow is a highly regulated process and expression of a functional pre-BCR represents a crucial checkpoint, common to human and Muse. In this review, we discuss pre-BCR analogies and differences between the two species leading to pre-B cell differentiation and proliferation. In addition. the mechanisms triggering pre-BCR activation are reviewed, taking into account the recent report of heparan sulfates and plectin 1 as stromal cell-derived pre-BCR ligands. Finally, ligand-induced pre-BCR activation models are proposed oil the bases of the differences reported for pre-BCR and IL7 dependencies in the two species. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：56 / 66

页数：11

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