Porous Chiral Metal-Organic Framework InH(D-C10H14O4)2 with Anionic-Type Diamond Network for High-Resolution Gas Chromatographic Enantioseparations

Metal-organic frameworks have large surface area, highly ordered pore structure and good chemical stability. In this study, a porous chiral metal-organic framework InH(D-C10H14O4)2(D-C10H14O4=D-(+)-camphoric acid) with a left-handed helical channel assembled from D-(+)-camphoric acid was used as chiral stationary phase in GC. InH(D-C10H14O4)2-coated open tubular columns with different inner diameters or lengths were prepared by a dynamic coating method for high-resolution GC separation of various types of organic compounds, including racemates, isomers, alkanes, alcohols, and Grob's test mixture. Their column efficiency, polarity, and selectivity were studied. The experimental results show that the stationary phase has excellent selectivity and also possesses good recognition ability toward these organic compounds, especially for chiral compounds.