Patient reported outcomes as endpoints in medical research

被引：85

作者：

Fairclough, DL

机构：

[1] Univ Colorado, Hlth Sci Ctr, Colorado Hlth Outcomes Program, Aurora, CO 80045 USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Prevent Med, Aurora, CO 80045 USA

来源：

STATISTICAL METHODS IN MEDICAL RESEARCH | 2004年 / 13卷 / 02期

关键词：

D O I：

10.1191/0962280204sm357ra

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

This review covers a number of the many design and analytic issues associated with clinical trials that incorporate patient reported outcomes as primary or secondary endpoints. We use a clinical trial designed to evaluate a new therapy for the prevention of migraines to illustrate how endpoints are defined by the objectives of the study, the methods for handling longitudinal assessments with multiple scales or outcomes, and the methods of analysis in the presence of missing data.

引用

页码：115 / 138

页数：24

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