Genomic organization of the interleukin-1 locus

被引：144

作者：

Taylor, SL ^{[1
]}

Renshaw, BR ^{[1
]}

Garka, KE ^{[1
]}

Smith, DE ^{[1
]}

Sims, JE ^{[1
]}

机构：

[1] Immunex Corp, Seattle, WA 98101 USA

来源：

GENOMICS | 2002年 / 79卷 / 05期

关键词：

cytokines; genome; human; inflammation; interleukin-1; intron; mice; multigene family;

D O I：

10.1006/geno.2002.6752

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent additions have expanded the interleukin (IL)-1 gene family to 10 members, We have determined the order, orientation, and intergenic distance of the nine IL-1 family genes that lie on human chromosome 2. We report cDNA sequences for the mouse orthologs of three of these genes. The order and orientation of the mouse genes have been mapped, and the mouse locus compared with the human locus. There is a break in the mouse locus of > 100 Mb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7.

引用

页码：726 / 733

页数：8

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