Active constituents against HIV-1 protease from Garcinia mangostana

被引：115

作者：

Chen, SX ^{[1
]}

Wan, M ^{[1
]}

Loh, BN ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE,DEPT BIOCHEM,SINGAPORE 119260,SINGAPORE

来源：

PLANTA MEDICA | 1996年 / 62卷 / 04期

关键词：

D O I：

10.1055/s-2006-957916

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active, known compounds. The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC50 = 5.12 +/- 0.41 mu M) and gamma-mangostin (IC50 = 4.81 +/- 0.32 mu M). The type of inhibition by both compounds is noncompetitive.

引用

页码：381 / 382

页数：2

共 17 条

[1] XANTHONES FROM GUTTIFERAE [J].

BENNETT, GJ ;

LEE, HH .

PHYTOCHEMISTRY, 1989, 28 (04) :967-998

[2] EXTRACTIVES FROM GUTTIFERAE .34. KOLAFLAVANONE, A NEW BIFLAVANONE FROM NUTS OF GARCINIA-KOLA HECKEL - APPLICATIONS OF C-13 NUCLEAR MAGNETIC-RESONANCE IN ELUCIDATION OF STRUCTURES OF FLAVONOIDS [J].

COTTERILL, PJ ;

SCHEINMANN, F ;

STENHOUSE, IA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1978, (06) :532-539

[3] MANNIFLAVANONE, A NEW 3,8-LINKED FLAVANONE DIMER FROM THE STEM BARK OF GARCINIA-MANNII [J].

CRICHTON, EG ;

WATERMAN, PG .

PHYTOCHEMISTRY, 1979, 18 (09) :1553-1557

[4]

GOPALAKRISHNAN C, 1980, INDIAN J EXP BIOL, V18, P843

[5] HIV INHIBITORY NATURAL-PRODUCTS .8. THE GUTTIFERONES, HIV-INHIBITORY BENZOPHENONES FROM SYMPHONIA-GLOBULIFERA, GARCINIA-LIVINGSTONEI GARCINIA-OVALIFOLIA AND CLUSIA-ROSEA [J].

GUSTAFSON, KR ;

BLUNT, JW ;

MUNRO, MHG ;

FULLER, RW ;

MCKEE, TC ;

CARDELLINA, JH ;

MCMAHON, JB ;

CRAGG, GM ;

BOYD, MR .

TETRAHEDRON, 1992, 48 (46) :10093-10102

[6] KOLANONE, A NOVEL POLYISOPRENYLATED BENZOPHENONE WITH ANTIMICROBIAL PROPERTIES FROM THE FRUIT OF GARCINIA-KOLA [J].

HUSSAIN, RA ;

OWEGBY, AG ;

PARIMOO, P ;

WATERMAN, PG .

PLANTA MEDICA, 1982, 44 (02) :78-81

[7] LACTONES, FLAVONOIDS AND BENZOPHENONES FROM GARCINIA-CONRAUANA AND GARCINIA-MANNII [J].

HUSSAIN, RA ;

WATERMAN, PG .

PHYTOCHEMISTRY, 1982, 21 (06) :1393-1396

[8] STUDIES IN XANTHONE SERIES .18. ISOLATION OF GAMMA-MANGOSTIN FROM GARCINIA-MANGOSTANA, AND PREPARATION OF NATURAL MANGOSTINS BY SELECTIVE DEMETHYLATION [J].

JEFFERSO.A ;

QUILLINA.AJ ;

SCHEINMA.F ;

SIM, KY .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1970, 23 (12) :2539-&

[9] The determination of enzyme dissociation constants [J].

Lineweaver, H ;

Burk, D .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1934, 56 :658-666

[10] HIV-1 PROTEASE INHIBITORY ACTIVITY OF L-694,746, A NOVEL METABOLITE OF L-689,502 [J].

LINGHAM, RB ;

ARISON, BH ;

COLWELL, LF ;

HSU, A ;

DEZENY, G ;

THOMPSON, WJ ;

GARRITY, GM ;

GAGLIARDI, MM ;

HARTNER, FW ;

DARKE, PL ;

BALANI, SK ;

PITZENBERGER, SM ;

MURPHY, JS ;

RAMJIT, HG ;

INAMINE, ES ;

TREIBER, LR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (03) :1456-1461

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