Active constituents against HIV-1 protease from Garcinia mangostana

被引：115

作者：

Chen, SX ^{[1
]}

Wan, M ^{[1
]}

Loh, BN ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE,DEPT BIOCHEM,SINGAPORE 119260,SINGAPORE

来源：

PLANTA MEDICA | 1996年 / 62卷 / 04期

关键词：

D O I：

10.1055/s-2006-957916

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active, known compounds. The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC50 = 5.12 +/- 0.41 mu M) and gamma-mangostin (IC50 = 4.81 +/- 0.32 mu M). The type of inhibition by both compounds is noncompetitive.

引用

页码：381 / 382

页数：2

共 17 条

[11]

SODATDISERENS I, 1989, HELV CHIM ACTA, V72, P1001

[12]

STOUT GH, 1968, J CHEM SOC CHEM COMM, P211

[13]

WAN M, 1995, BIOCHEM MOL BIOL INT, V35, P899

[14]

WARREN PA, 1971, TETRAHEDRON, V27, P1625

[15] XANTHONES, BENZOPHENONES AND TRITERPENES FROM THE STEM BARK OF GARCINIA-OVALIFOLIA [J].

WATERMAN, PG ;

CRICHTON, EG .

PLANTA MEDICA, 1980, 40 (04) :351-355

[16] THE STRUCTURE OF MANGOSTIN [J].

YATES, P ;

STOUT, GH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (07) :1691-1700

[17]

ZHENG MS, 1990, CHINESE MED J-PEKING, V103, P160

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