A Distinct Function of Regulatory T Cells in Tissue Protection

被引：767

作者：

Arpaia, Nicholas ^{[1
,2
]}

Green, Jesse A. ^{[1
,2
]}

Moltedo, Bruno ^{[1
,2
]}

Arvey, Aaron ^{[1
,2
]}

Hemmers, Saskia ^{[1
,2
]}

Yuan, Shaopeng ^{[1
,2
,3
]}

Treuting, Piper M. ^{[4
]}

Rudensky, Alexander Y. ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Program Immunol, New York, NY 10065 USA

[3] Rockefeller Univ, David Rockefeller Grad Program, New York, NY 10065 USA

[4] Univ Washington, Dept Comparat Med, Sch Med, Seattle, WA 98195 USA

来源：

CELL | 2015年 / 162卷 / 05期

关键词：

AMPHIREGULIN; INFLAMMATION; FOXP3; DIFFERENTIATION; INTERLEUKIN-10; POPULATION; RESPONSES;

D O I：

10.1016/j.cell.2015.08.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulatory T (Treg) cells suppress immune responses to a broad range of non-microbial and microbial antigens and indirectly limit immune inflammation-inflicted tissue damage by employing multiple mechanisms of suppression. Here, we demonstrate that selective Treg cell deficiency in amphiregulin leads to severe acute lung damage and decreased blood oxygen concentration during influenza virus infection without any measureable alterations in Treg cell suppressor function, antiviral immune responses, or viral load. This tissue repair modality is mobilized in Treg cells in response to inflammatory mediator IL-18 or alarmin IL-33, but not by TCR signaling that is required for suppressor function. These results suggest that, during infectious lung injury, Treg cells have a major direct and non-redundant role in tissue repair and maintenance-distinct from their role in suppression of immune responses and inflammation-and that these two essential Treg cell functions are invoked by separable cues.

引用

页码：1078 / 1089

页数：12

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