What is the real contribution of extrahepatic cells to liver regeneration?

被引：7

作者：

Eguchi, Susumu ^{[1
]}

Kanematsu, Takashi ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Surg, Nagasaki 8528501, Japan

来源：

SURGERY TODAY | 2009年 / 39卷 / 01期

关键词：

Extrahepatic stem cells; Liver regeneration; Transdifferentiation; Cell fusion; BONE-MARROW-CELLS; HEPATOCYTE REGENERATION; MYELOMONOCYTIC CELLS; PARTIAL-HEPATECTOMY; PROGENITOR CELLS; STEM-CELLS; RAT-LIVER; FUSION; TRANSPLANTATION; MODEL;

D O I：

10.1007/s00595-008-3836-1

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

Extrahepatic cells, especially bone marrow (BM) cells, might contribute to liver repair, but recent published evidence suggests that they do not play a role in the normally regenerating liver. The mechanism by which extrahepatic cells express a liver-specific function in the liver, whether by transdifferentiation or by cell fusion, remains unclear. In this review, we investigate the status of findings on this controversial subject and summarize the recent research.

引用

页码：1 / 4

页数：4

共 31 条

[1]

Replacement of liver venous endothelium [J].

Baccarani, U ;

Donini, A ;

Risaliti, A ;

Bresadola, F .

LANCET, 2001, 357 (9274) :2137-2137

[2]

Endothetial progenitor cells contribute to accelerated liver regeneration [J].

Beaudry, Pau ;

Hida, Yasuhiro ;

Udagawa, Taturo ;

Alwayn, Ian P. ;

Greene, Arin K. ;

Arsenault, Daniette ;

Folkman, Judah ;

Heymach, John V. ;

Ryeom, Sandra ;

Puder, Mark .

JOURNAL OF PEDIATRIC SURGERY, 2007, 42 (07) :1190-1198

[3]

Cells of origin of small hepatocyte-like progenitor cells in the retrorsine model of rat liver injury and regeneration [J].

Best, D. Hunter ;

Coleman, William B. .

JOURNAL OF HEPATOLOGY, 2008, 48 (02) :369-371

[4]

Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers [J].

Brulport, Marc ;

Schormann, Wiebke ;

Bauer, Alexander ;

Hermes, Matthias ;

Elsner, Carohn ;

Hammersen, Friedrich Jakob ;

Beerheide, Walter ;

Spitkovsky, Dimitry ;

Hdrtig, Wolfgang ;

Nussler, Andreas ;

Horn, Lars Christian ;

Edelmann, Jeanett ;

Pelz-Ackermann, Oliver ;

Petersen, Jrg ;

Kamprad, Manj A. ;

Von Mach, Marc ;

Lupp, Amehe ;

Zulewski, Henryk ;

Hengstlerl, Jan G. .

HEPATOLOGY, 2007, 46 (03) :861-870

[5]

Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners [J].

Camargo, FD ;

Finegold, M ;

Goodell, MA .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (09) :1266-1270

[6]

Reevaluation of bone marrow-derived cells as a source for hepatocyte regeneration [J].

Cantz, T ;

Sharma, AD ;

Jochheim-Richter, A ;

Arseniev, L ;

Klein, C ;

Manns, MP ;

Ott, M .

CELL TRANSPLANTATION, 2004, 13 (06) :659-666

[7]

Conzelmann LO, 2007, EXP BIOL MED, V232, P571

[8]

Liver regeneration in a retrorsine/CCl4-induced acute liver failure model:: do bone marrow-derived cells contribute? [J].

Dahlke, MH ;

Popp, FC ;

Bahlmann, FH ;

Aselmann, H ;

Jäger, MD ;

Neipp, M ;

Piso, P ;

Klempnauer, M ;

Schlitt, HJ .

JOURNAL OF HEPATOLOGY, 2003, 39 (03) :365-373

[9]

No evidence of hematopoietic stem cell mobilization in patients submitted to hepatectomy or in patients with acute on chronic liver failure [J].

Di Campli, C ;

Piscaglia, AC ;

Giuliante, F ;

Rutella, S ;

Bonanno, G ;

Zocco, MA ;

Ardito, F ;

Nuzzo, G ;

Mancuso, S ;

Leone, G ;

Gasbarrini, G ;

Pola, P ;

Gasbarrini, A .

TRANSPLANTATION PROCEEDINGS, 2005, 37 (06) :2563-2566

[10]

Eguchi S, 1996, HEPATOLOGY, V24, P1452

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