Near-Infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution

被引:261
作者
Lee, Chia-Hung [1 ]
Cheng, Shih-Hsun [2 ,5 ]
Wang, Yujing [1 ]
Chen, Yu-Ching [1 ]
Chen, Nai-Tzu [2 ]
Souris, Jeffrey [6 ]
Chen, Chin-Tu [6 ]
Mou, Chung-Yuan [7 ]
Yang, Chung-Shi [1 ,3 ,4 ]
Lo, Leu-Wei [2 ]
机构
[1] Natl Hlth Res Inst, Ctr Nanomed Res, Zhunan 350, Miaoli, Taiwan
[2] Natl Hlth Res Inst, Div Med Engn Res, Zhunan 350, Miaoli, Taiwan
[3] Natl Chi Nan Univ, Dept Appl Chem, Puli 545, Nantou, Taiwan
[4] Natl Chi Nan Univ, Grad Inst Biomed & Biomed Technol, Puli 545, Nantou, Taiwan
[5] Natl Tsing Hua Univ, Inst NanoEngn & MicroSyst, Hsinchu 300, Taiwan
[6] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA
[7] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
关键词
SEMICONDUCTOR QUANTUM DOTS; MRI CONTRAST AGENTS; INDOCYANINE-GREEN; DRUG-DELIVERY; CONTROLLED-RELEASE; GENE DELIVERY; CANCER-CELLS; SOL-GEL; SYSTEM; BREAST;
D O I
10.1002/adfm.200800753
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The characterization of near-infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN-TA) with the average size of 50-100 nm was synthesized with incorporation of the TA groups into the framework of MSN. It was further adsorbed with indocyanine green (ICG) by electrostatic attraction to render MSN-TA-ICG as an efficient NIR contrast agent for in vivo optical imaging. The studies in stability of MSN-TA-ICG against pH Indicated the bonding is stable over the range from acidic to physiological pH. The in vivo biodistribution of MSN-TA-ICG in anesthetized rat demonstrated a rather strong and stable fluorescence of MSN-TA-ICG that prominent in the organ of liver. Transmission electron microscopy (TEM) imaging and elemental analysis of silicon further manifested the physical and quantitative residences of MSN-TA-ICG in major organs. This is the first report of MSN functionalized with NIR-ICG capable of optical imaging in vivo.
引用
收藏
页码:215 / 222
页数:8
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