Interpreting the protein language using proteomics

被引：378

作者：

Jensen, Ole N. ^{[1
]}

机构：

[1] Univ So Denmark, Dept Biochem & Mol Biol, Prot Res Grp, DK-5230 Odense M, Denmark

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 06期

关键词：

D O I：

10.1038/nrm1939

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Post-translational modifications define the functional and structural plasticity of proteins in archaea, prokaryotes and eukaryotes. Multi-site protein modification modulates protein activity and macromolecular interactions and is involved in a range of fundamental molecular processes. Combining state-of-the-art technologies in molecular cell biology, protein mass spectrometry and bioinformatics, it is now feasible to discover and study the structural and functional roles of distinct protein post-translational modifications.

引用

页码：391 / 403

页数：13

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