Cell biology - Lipid membranes shape up

被引：43

作者：

Scales, SJ ^{[1
]}

Scheller, RH ^{[1
]}

机构：

[1] Stanford Univ, Howard Hughes Med Inst, Sch Med, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA

来源：

NATURE | 1999年 / 401卷 / 6749期

关键词：

D O I：

10.1038/43582

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When synaptic vesicles are recycled, they are 'pinched' off from the presynaptic membrane. A protein called dynamin was thought to be the 'pinchase', but it now turns out that dynamin's function is to recruit another protein, endophilin I, to the neck of the vesicle. Endophilin I affects the composition of the lipids in the vesicle's membrane, influencing its curvature and facilitating the pinching process.

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页码：123 / 124

页数：2

相关论文

共 11 条

[1]

CHERNOMORDIK L, 1995, J MEMBRANE BIOL, V146, P1

[2] Identification of the major synaptojanin-binding proteins in brain [J].

deHeuvel, E ;

Bell, AW ;

Ramjaun, AR ;

Wong, K ;

Sossin, WS ;

McPherson, PS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (13) :8710-8716

[3] A function for the AP3 coat complex in synaptic vesicle formation from endosomes [J].

Faúndez, V ;

Horng, JT ;

Kelly, RB .

CELL, 1998, 93 (03) :423-432

[4] Cell biology - Boa constrictor or rattlesnake? [J].

Kirchhausen, T .

NATURE, 1999, 398 (6727) :470-471

[5] Kinetics and regulation of fast endocytosis at hippocampal synapses [J].

Klingauf, J ;

Kavalali, ET ;

Tsien, RW .

NATURE, 1998, 394 (6693) :581-585

[6] SH3 domain-dependent interactions of endophilin with amphiphysin [J].

Micheva, KD ;

Ramjaun, AR ;

Kay, BK ;

McPherson, PS .

FEBS LETTERS, 1997, 414 (02) :308-312

[7] The SH3p4/Sh3p8/SH3p13 protein family: Binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain [J].

Ringstad, N ;

Nemoto, Y ;

DeCamilli, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8569-8574

[8]

RINGSTAD N, IN PRESS NEURON

[9] Biogenesis of synaptic-like microvesicles in perforated PC12 cells [J].

Schmidt, A ;

Huttner, WB .

METHODS-A COMPANION TO METHODS IN ENZYMOLOGY, 1998, 16 (02) :160-169

[10] Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid [J].

Schmidt, A ;

Wolde, M ;

Thiele, C ;

Fest, W ;

Kratzin, H ;

Podtelejnikov, AV ;

Witke, W ;

Huttner, WB ;

Söling, HD .

NATURE, 1999, 401 (6749) :133-141