Rho GTPase signalling pathways in the morphological changes associated with apoptosis

被引：199

作者：

Coleman, ML ^{[1
]}

Olson, MF ^{[1
]}

机构：

[1] Inst Canc Res, Canc Res Campaign, Ctr Cell & Mol Biol, London SW3 6JB, England

来源：

CELL DEATH AND DIFFERENTIATION | 2002年 / 9卷 / 05期

关键词：

Rho; Rac; ROCK; actin cytoskeleton; myosin light chain; phagocytosis; blebbing;

D O I：

10.1038/sj.cdd.4400987

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The killing and removal of superfluous cells is an important step during embryonic development, tissue homeostasis, wound repair and the resolution of inflammation. A specific sequence of biochemical events leads to a form of cell death termed apoptosis, and ultimately to the disassembly of the dead cell for phagocytosis. Dynamic rearrangements of the actin cytoskeleton are central to the morphological changes observed both in apoptosis and phagocytosis. Recent research has highlighted the importance of Rho GTPase signalling pathways to these changes in cellular architecture, In this review, we will discuss how these signal transduction pathways affect the structure of the actin cytoskeleton and allow for the efficient clearance of apoptotic cells.

引用

页码：493 / 504

页数：12

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