Translational Control of Long-Lasting Synaptic Plasticity and Memory

被引：749

作者：

Costa-Mattioli, Mauro ^{[1
,4
]}

Sossin, Wayne S. ^{[2
]}

Klann, Eric ^{[3
]}

Sonenberg, Nahum ^{[1
,4
]}

机构：

[1] McGill Univ, McGill Canc Ctr, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

[3] NYU, Ctr Neural Sci, New York, NY 10003 USA

[4] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

来源：

NEURON | 2009年 / 61卷 / 01期

关键词：

X MENTAL-RETARDATION; INITIATION-FACTOR; 4E; LOCAL PROTEIN-SYNTHESIS; MESSENGER-RNA TRANSLATION; CAP-DEPENDENT TRANSLATION; CYTOPLASMIC POLYADENYLATION ELEMENT; ELONGATION-FACTOR; 1-ALPHA; RAPAMYCIN-SENSITIVE MANNER; DENDRITIC BC1 RNA; KINASE M-ZETA;

D O I：

10.1016/j.neuron.2008.10.055

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits and thus long-term modifications in behavior. Translational control is important for regulating both general protein synthesis and synthesis of specific proteins in response to neuronal activity. In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases.

引用

页码：10 / 26

页数：17

共 234 条

[1] Early nonsense: mRNA decay solves a translational problem [J].

Amrani, Nadia ;

Sachs, Matthew S. ;

Jacobson, Allan .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (06) :415-425

[2] Distinct role of long 3′ UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons [J].

An, Juan Ji ;

Gharami, Kusumika ;

Liao, Guey-Ying ;

Woo, Newton H. ;

Lau, Anthony G. ;

Vanevski, Filip ;

Torre, Enrique R. ;

Jones, Kevin R. ;

Feng, Yue ;

Lu, Bai ;

Xu, Baoji .

CELL, 2008, 134 (01) :175-187

[3]

[Anonymous], 2007, SCI SINGAL, DOI DOI 10.1126/STKE.3672007RE1

[4] Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity [J].

Antion, Marcia D. ;

Merhav, Maayan ;

Hoeffer, Charles A. ;

Reis, Gerald ;

Kozma, Sara C. ;

Thomas, George ;

Schuman, Erin M. ;

Rosenblum, Kobi ;

Klann, Eric .

LEARNING & MEMORY, 2008, 15 (01) :29-38

[5] mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice [J].

Antion, Marcia D. ;

Hou, Lingfei ;

Wong, Helen ;

Hoeffer, Charles A. ;

Klann, Eric .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (09) :2996-3007

[6] Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development [J].

Arquier, N ;

Bourouis, M ;

Colombani, J ;

Léopold, P .

CURRENT BIOLOGY, 2005, 15 (01) :19-23

[7] The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain [J].

Aschrafi, A ;

Cunningham, BA ;

Edelman, GM ;

Vanderklish, PW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (06) :2180-2185

[8] Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila [J].

Ashraf, SI ;

McLoon, AL ;

Sclarsic, SM ;

Kunes, S .

CELL, 2006, 124 (01) :191-205

[9] Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-cependent protein kinase II [J].

Atkins, CM ;

Nozaki, N ;

Shigeri, Y ;

Soderling, TR .

JOURNAL OF NEUROSCIENCE, 2004, 24 (22) :5193-5201

[10]

Bagni Claudia, 2008, Proc Natl Acad Sci U S A, V105, pE19, DOI 10.1073/pnas.0801034105

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