Translational Control of Long-Lasting Synaptic Plasticity and Memory

被引:749
作者
Costa-Mattioli, Mauro [1 ,4 ]
Sossin, Wayne S. [2 ]
Klann, Eric [3 ]
Sonenberg, Nahum [1 ,4 ]
机构
[1] McGill Univ, McGill Canc Ctr, Montreal, PQ H3G 1Y6, Canada
[2] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada
[3] NYU, Ctr Neural Sci, New York, NY 10003 USA
[4] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
关键词
X MENTAL-RETARDATION; INITIATION-FACTOR; 4E; LOCAL PROTEIN-SYNTHESIS; MESSENGER-RNA TRANSLATION; CAP-DEPENDENT TRANSLATION; CYTOPLASMIC POLYADENYLATION ELEMENT; ELONGATION-FACTOR; 1-ALPHA; RAPAMYCIN-SENSITIVE MANNER; DENDRITIC BC1 RNA; KINASE M-ZETA;
D O I
10.1016/j.neuron.2008.10.055
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits and thus long-term modifications in behavior. Translational control is important for regulating both general protein synthesis and synthesis of specific proteins in response to neuronal activity. In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases.
引用
收藏
页码:10 / 26
页数:17
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