The role of regulatory RNA in cognitive evolution

被引：37

作者：

Barry, Guy ^{[1
]}

Mattick, John S. ^{[1
,2
,3
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Garvan Inst Med Res, Sydney, NSW 2010, Australia

[3] Univ New S Wales, Sydney, NSW 2052, Australia

来源：

TRENDS IN COGNITIVE SCIENCES | 2012年 / 16卷 / 10期

关键词：

COPY NUMBER VARIATION; LONG NONCODING RNAS; L1; RETROTRANSPOSITION; EPIGENETIC MECHANISMS; MICRORNA EXPRESSION; RADIAL GLIA; HUMAN BRAIN; DNA; TRANSCRIPTOME; REPEATS;

D O I：

10.1016/j.tics.2012.08.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

The evolution of the human brain has resulted in the emergence of higher-order cognitive abilities, such as reasoning, planning and social awareness. Although there has been a concomitant increase in brain size and complexity, and component diversification, we argue that RNA regulation of epigenetic processes, RNA editing, and the controlled mobilization of transposable elements have provided the major substrates for cognitive advance. We also suggest that these expanded capacities and flexibilities have led to the collateral emergence of psychiatric fragilities and conditions.

引用

收藏

页码：497 / 503

页数：7

相关论文

共 92 条

[1]

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 [J].

Amir, RE ;

Van den Veyver, IB ;

Wan, M ;

Tran, CQ ;

Francke, U ;

Zoghbi, HY .

NATURE GENETICS, 1999, 23 (02) :185-188

[2]

Widespread A-to-I RNA editing of alu-containing mRNAs in the human transcriptome [J].

Athanasiadis, A ;

Rich, A ;

Maas, S .

PLOS BIOLOGY, 2004, 2 (12) :2144-2158

[3]

Equal Numbers of Neuronal and Nonneuronal Cells Make the Human Brain an Isometrically Scaled-Up Primate Brain [J].

Azevedo, Frederico A. C. ;

Carvalho, Ludmila R. B. ;

Grinberg, Lea T. ;

Farfel, Jose Marcelo ;

Ferretti, Renata E. L. ;

Leite, Renata E. P. ;

Jacob Filho, Wilson ;

Lent, Roberto ;

Herculano-Houzel, Suzana .

JOURNAL OF COMPARATIVE NEUROLOGY, 2009, 513 (05) :532-541

[4]

Somatic retrotransposition alters the genetic landscape of the human brain [J].

Baillie, J. Kenneth ;

Barnett, Mark W. ;

Upton, Kyle R. ;

Gerhardt, Daniel J. ;

Richmond, Todd A. ;

De Sapio, Fioravante ;

Brennan, Paul ;

Rizzu, Patrizia ;

Smith, Sarah ;

Fell, Mark ;

Talbot, Richard T. ;

Gustincich, Stefano ;

Freeman, Thomas C. ;

Mattick, John S. ;

Hume, David A. ;

Heutink, Peter ;

Carninci, Piero ;

Jeddeloh, Jeffrey A. ;

Faulkner, Geoffrey J. .

NATURE, 2011, 479 (7374) :534-537

[5]

Evolution of the cerebellar cortex: The selective expansion of prefrontal-projecting cerebellar lobules [J].

Balsters, J. H. ;

Cussans, E. ;

Diedrichsen, J. ;

Phillips, K. A. ;

Preuss, T. M. ;

Rilling, J. K. ;

Ramnani, N. .

NEUROIMAGE, 2010, 49 (03) :2045-2052

[6]

MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[7]

RNA editing by adenosine deaminases that act on RNA [J].

Bass, BL .

ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :817-846

[8]

Schizophrenia is associated with an increase in cortical microRNA biogenesis [J].

Beveridge, N. J. ;

Gardiner, E. ;

Carroll, A. P. ;

Tooney, P. A. ;

Cairns, M. J. .

MOLECULAR PSYCHIATRY, 2010, 15 (12) :1176-1189

[9]

DNA Demethylation Dynamics [J].

Bhutani, Nidhi ;

Burns, David M. ;

Blau, Helen M. .

CELL, 2011, 146 (06) :866-872

[10]

A survey of RNA editing in human brain [J].

Blow, M ;

Futreal, PA ;

Wooster, R ;

Stratton, MR .

GENOME RESEARCH, 2004, 14 (12) :2379-2387

← 1 2 3 4 5 6 7 8 9 10 →