DNA Demethylation Dynamics

被引：636

作者：

Bhutani, Nidhi ^{[1
]}

Burns, David M. ^{[1
]}

Blau, Helen M. ^{[1
]}

机构：

[1] Stanford Univ, Baxter Lab Stem Cell Biol, Inst Stem Cell Biol & Regenerat Med, Dept Microbiol & Immunol,Sch Med, Stanford, CA 94305 USA

来源：

CELL | 2011年 / 146卷 / 06期

关键词：

EMBRYONIC STEM-CELLS; BASE EXCISION-REPAIR; METHYLATION PATTERNS; PATERNAL GENOME; PREIMPLANTATION DEVELOPMENT; SOMATIC HYPERMUTATION; GENE-EXPRESSION; 5-HYDROXYMETHYLCYTOSINE; MOUSE; TET1;

D O I：

10.1016/j.cell.2011.08.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The discovery of cytosine hydroxymethylation (5hmC) suggested a simple means of demethylating DNA and activating genes. Further experiments, however, unearthed an unexpectedly complex process, entailing both passive and active mechanisms of DNA demethylation by the ten-eleven translocation (TET) and AID/APOBEC families of enzymes. The consensus emerging from these studies is that removal of cytosine methylation in mammalian cells can occur by DNA repair. These reports highlight that in certain contexts, DNA methylation is not fixed but dynamic, requiring continuous regulation.

引用

收藏

页码：866 / 872

页数：7

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