HIV-1 gp41 fusogenic function triggers autophagy in uninfected cells

被引：110

作者：

Denizot, Melanie ^{[1
]}

Varbanov, Mihayl ^{[1
]}

Espert, Lucile ^{[1
]}

Robert-Hebmann, Veronique ^{[1
]}

Sagnier, Sophie ^{[1
]}

Garcia, Elisabet ^{[2
]}

Curriu, Marta ^{[2
]}

Mamoun, Robert ^{[3
,4
]}

Blanco, Julia ^{[2
]}

Biard-Piechaczyk, Martine ^{[1
]}

机构：

[1] UM1, UM2, CPBS, CNRS,Inst Biol, F-34965 Montpellier 2, France

[2] Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Fdn Irsi Caixa, Inst Recerca Ciencies Salut Germans Trias & Pujol, Catalonia, Spain

[3] UM1, UM2, CNRS, DIMNP,UMR5235, F-34965 Montpellier 2, France

[4] INSERM, F-75654 Paris 13, France

来源：

AUTOPHAGY | 2008年 / 4卷 / 08期

关键词：

HIV-1; autophagy; envelope glycoproteins; gp41; CXCR4; cell-to-cell fusion; syncytia; cell death; bystander cells;

D O I：

10.4161/auto.6880

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Abbreviations: CHR, C-terminal heptad repeat; Env, HIV-1 envelope glycoproteins (gp 120 + gp41); Env.41.2, Env in which gp41 presents a mutation in the second amino acid of gp41 (gp41.2); Env.Delta t, Env in which the last 144 a.a. of the gp41 cytoplasmic tail were deleted (gp41.Delta t); ERK, extracellular signal regulated kinase; FP, fusion peptide; ICL, intracellular loop; ICLm, mutated intracellular loop; Jak, janus kinase; NHR, N-terminal heptad repeat, STAT signal transduction and activation of transcription; TEM, transmission electron microscopy; x4 CXCR4-using HIV-1 isolates; 6-HB, 6-helix bundle structure

引用

页码：998 / 1008

页数：11

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