Reprogrammed Cells for Disease Modeling and Regenerative Medicine

被引：100

作者：

Cherry, Anne B. C. ^{[1
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Daley, George Q. ^{[1
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机构：

[1] Childrens Hosp, Howard Hughes Med Inst, Stem Cell Transplantat Program, Div Pediat Hematol Oncol,Manton Ctr Orphan Dis Re, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[5] Broad Inst, Boston, MA 02115 USA

[6] Harvard Stem Cell Inst, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF MEDICINE, VOL 64 | 2013年 / 64卷

关键词：

induced pluripotent stem (iPS) cells; history of reprogramming; cellular therapy; gene correction; hematology; PLURIPOTENT STEM-CELLS; HEMATOPOIETIC DIFFERENTIATION; AORTIC ENDOTHELIUM; APLASTIC-ANEMIA; GENE CORRECTION; TRANSPLANTATION; FIBROBLASTS; EXPRESSION; MUTATIONS; GENERATION;

D O I：

10.1146/annurev-med-050311-163324

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The conversion of somatic cells into pluripotent cells is transforming the way diseases are researched and treated. Induced pluripotent stem (iPS) cells' promise may soon be realized in the field of hematology, as hematopoietic stem cell transplants are already commonplace in clinics around the world. We provide a current comparison between induced pluripotent and embryonic stem cells, describe progress toward modeling hematological disorders using iPS cells, and illustrate the hurdles that must be overcome before iPS cell therapies will be available in clinics.

引用

页码：277 / 290

页数：14

共 67 条

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