Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors

被引：13

作者：

Burnett, DA ^{[1
]}

Caplen, MA ^{[1
]}

Browne, ME ^{[1
]}

Zhau, HR ^{[1
]}

Altmann, SW ^{[1
]}

Davis, HR ^{[1
]}

Clader, JW ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)00752-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fluorescent analogues of the cholesterol absorption inhibitor (CAI), Sch 58235, have been designed and synthesized as single enantiomers. Biological testing reveals that they are potent CAIs and are suitable tools for the investigation of the azetidinone CAI mechanism of action (MOA). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：315 / 318

页数：4

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