NUCLEIC-ACID RELATED-COMPOUNDS .59. SOLVENT, NOT PALLADIUM OXIDATION-STATE, IS THE PRIMARY DETERMINANT FOR SUCCESSFUL COUPLING OF TERMINAL ALKYNES WITH IODO-NUCLEOSIDES

被引：68

作者：

ROBINS, MJ ^{[1
]}

VINAYAK, RS ^{[1
]}

WOOD, SG ^{[1
]}

机构：

[1] APPL BIOSYST INC,PROC DEV DNA,FOSTER CITY,CA 94404

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)97456-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Coupling of iodo-nucleosides with terminal alkynes such as 3-(acylamino)propynes, whose initial products readily undergo secondary cyclization reactions, can be effected smoothly by the standard catalysis with (Ph3P)2PdCl2/CuI/Et3N in dimethylformamide. © 1990.

引用

收藏

页码：3731 / 3734

页数：4

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