Nuclear hormone receptors in T lymphocytes

被引:212
作者
Winoto, A
Littman, DR
机构
[1] NYU, Sch Med, Skirball Inst Biomol Med, Howard Hughes Med Inst, New York, NY 10016 USA
[2] Univ Calif Berkeley, Dept Mol & Cell Biol, LSA 469, Berkeley, CA 94720 USA
关键词
D O I
10.1016/S0092-8674(02)00710-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Among the numerous steroid and orphan nuclear receptors encoded within mammalian genomes, several are involved in regulating immune system functions. We review here recent studies on the glucocorticoid receptor and the orphan receptors Nur77 and RORgamma. These molecules play key roles in the development and the effector functions of T lymphocytes.
引用
收藏
页码:S57 / S66
页数:10
相关论文
共 91 条
[21]   A link between cell cycle and cell death:: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis [J].
Gil-Gómez, G ;
Berns, A ;
Brady, HJM .
EMBO JOURNAL, 1998, 17 (24) :7209-7218
[22]  
Glass CK, 2000, GENE DEV, V14, P121
[23]   Glucocorticoids and the thymus: the view from the middle of the road [J].
Godfrey, DI ;
Purton, JF ;
Boyd, RL ;
Purton, JF ;
Cole, TJ .
TRENDS IN IMMUNOLOGY, 2001, 22 (05) :243-243
[24]  
HARMSEN A, 2002, IN PRESS J IMMUNOL
[25]   RORγt, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells [J].
He, YW ;
Deftos, ML ;
Ojala, EW ;
Bevan, MJ .
IMMUNITY, 1998, 9 (06) :797-806
[26]   Cross-talk between glucocorticoid receptor and AP-1 [J].
Herrlich, P .
ONCOGENE, 2001, 20 (19) :2465-2475
[27]   ROR-GAMMA - THE 3RD MEMBER OF ROR-RZR ORPHAN RECEPTOR SUBFAMILY THAT IS HIGHLY EXPRESSED IN SKELETAL-MUSCLE [J].
HIROSE, T ;
SMITH, RJ ;
JETTEN, AM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 205 (03) :1976-1983
[28]  
JAMESON SC, 1995, ANNU REV IMMUNOL, V13, P93, DOI 10.1146/annurev.iy.13.040195.000521
[29]   Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling [J].
Jamieson, CAM ;
Yamamoto, KR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (13) :7319-7324
[30]   A role for glucocorticoids in the thymus? [J].
Jondal, M ;
Pazirandeh, A ;
Okret, S .
TRENDS IN IMMUNOLOGY, 2001, 22 (04) :185-186