Emerging roles of DP and CRTH2 in allergic inflammation

被引：182

作者：

Kostenis, Evi

Ulven, Trond

机构：

[1] Univ Bonn, Inst Pharmaceut Biol, D-53155 Bonn, Germany

[2] Univ So Denmark, Dept Chem, DK-5230 Odense M, Denmark

来源：

TRENDS IN MOLECULAR MEDICINE | 2006年 / 12卷 / 04期

关键词：

D O I：

10.1016/j.molmed.2006.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipid mediator prostaglandin D-2 (PGD(2)) has long been implicated in various inflammatory diseases including asthma. PGD(2) elicits biological responses by activating two seven-transmembrane (7TM) G-protein-coupled receptors, the D-prostanoid receptor DP and the chemoattractant receptor homologous-molecule expressed on T-helper-type-2 cells (CRTH2), which are linked to different signaling pathways. Understanding how immune cells integrate and coordinate signals that are triggered by the same ligand is crucial for the development of novel anti-inflammatory therapies. Here, we examine the roles of DP and CRTH2 in the orchestration of complex inflammatory processes, and discuss their importance as emerging targets for the treatment of asthma and inflammatory diseases.

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页码：148 / 158

页数：11

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