Neuronal characteristics of small-cell lung cancer

被引：65

作者：

Onganer, PU ^{[1
]}

Seckl, MJ ^{[1
]}

Djamgoz, MBA ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London SW7 2AZ, England

来源：

BRITISH JOURNAL OF CANCER | 2005年 / 93卷 / 11期

基金：

英国惠康基金;

关键词：

small-cell lung cancer; neuronal markers; voltage-gated ion channels;

D O I：

10.1038/sj.bjc.6602857

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Wide ranging experimental evidence suggests that human small-cell lung cancer (SCLC) has a number of molecular and subcellular characteristics normally associated with neurones. This review outlines and discusses these characteristics in the light of recent developments in the field. Emphasis is placed upon neuronal cell adhesion molecules, neurone-restrictive silencer factor, neurotransmitters/peptides and voltage-gated ion, especially Na+ channels. The hypothesis is put forward that acquisition of such characteristics and the membrane 'excitability' that would follow can accelerate metastatic progression. The clinical potential of the neuronal characteristics of SCLC, in particular ion channel expression/activity, is discussed in relation to possible novel diagnostic and therapeutic modalities.

引用

页码：1197 / 1201

页数：5

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