Parkinson's disease: an update on pathogenesis and treatment

被引：28

作者：

Foltynie, Tom ^{[1
,2
]}

Kahan, Joshua ^{[2
]}

机构：

[1] Natl Hosp Neurol & Neurosurg, Box 146,Queen Sq, London WC1N 3BG, England

[2] UCL Inst Neurol, Sobell Dept Motor Neurosci, London WC1N 3BG, England

来源：

JOURNAL OF NEUROLOGY | 2013年 / 260卷 / 05期

关键词：

Parkinson's disease; Pathogenesis; Treatment; Update; ALPHA-SYNUCLEIN; NEUROTROPHIC FACTOR; SUBSTANTIA-NIGRA; CONTROLLED-TRIAL; DOPAMINERGIC-NEURONS; RODENT MODELS; GENE-THERAPY; COMPLEX-I; GLUCOCEREBROSIDASE; BRAIN;

D O I：

10.1007/s00415-013-6915-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Parkinson's disease research field is a rapidly moving one, as many of the relevant processes underlying PD neurodegeneration are being deciphered, enabling novel approaches to treatment to be assessed both in the laboratory and in the clinic. This review aims to highlight the most relevant updates in the PD field, with emphasis on research that may help lead towards an improvement in the treatment of this condition.

引用

页码：1433 / 1440

页数：8

共 76 条

[1] Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease
Abramov, Andrey Yurevich
Gegg, Matthew
Grunewald, Anne
Wood, Nicholas William
Klein, Christine
Schapira, Anthony Henry Vernon
[J]. PLOS ONE, 2011, 6 (10):
[2] Creatine and Its Potential Therapeutic Value for Targeting Cellular Energy Impairment in Neurodegenerative Diseases
Adhihetty, Peter J.
Beal, M. Flint
[J]. NEUROMOLECULAR MEDICINE, 2008, 10 (04) : 275 - 290
[3] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, Lydia
Seow, Yiqi
Yin, HaiFang
Betts, Corinne
Lakhal, Samira
Wood, Matthew J. A.
[J]. NATURE BIOTECHNOLOGY, 2011, 29 (04) : 341 - U179
[4] Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
Alvarez-Erviti, Lydia
Seow, Yiqi
Schapira, Anthony H.
Gardiner, Chris
Sargent, Ian L.
Wood, Matthew J. A.
Cooper, J. Mark
[J]. NEUROBIOLOGY OF DISEASE, 2011, 42 (03) : 360 - 367
[5] Mitochondrial metabolism in Parkinsons disease impairs quality control autophagy by hampering microtubule-dependent traffic
Arduino, Daniela M.
Esteves, A. Raquel
Cortes, Luisa
Silva, Diana F.
Patel, Bindi
Grazina, Manuela
Swerdlow, Russell H.
Oliveira, Catarina R.
Cardoso, Sandra M.
[J]. HUMAN MOLECULAR GENETICS, 2012, 21 (21) : 4680 - 4702
[6] Aviles-Olmos I, 2013, J CLIN INVE IN PRESS
[7] Parkinson's disease, insulin resistance and novel agents of neuroprotection
Aviles-Olmos, Iciar
Limousin, Patricia
Lees, Andrew
Foltynie, Thomas
[J]. BRAIN, 2013, 136 : 374 - 384
[8] AFQ056 Treatment of Levodopa-Induced Dyskinesias: Results of 2 Randomized Controlled Trials
Berg, Daniela
Godau, Jana
Trenkwalder, Claudia
Eggert, Karla
Csoti, Iiona
Storch, Alexander
Huber, Heiko
Morelli-Canelo, Monica
Stamelou, Maria
Ries, Vincent
Wolz, Martin
Schneider, Christine
Di Paolo, Therese
Gasparini, Fabrizio
Hariry, Sam
Vandemeulebroecke, Marc
Abi-Saab, Walid
Cooke, Katy
Johns, Donald
Gomez-Mancilla, Baltazar
[J]. MOVEMENT DISORDERS, 2011, 26 (07) : 1243 - 1250
[9] Gene therapy: a viable therapeutic strategy for Parkinson's disease?
Berry, Alexander L.
Foltynie, Thomas
[J]. JOURNAL OF NEUROLOGY, 2011, 258 (02) : 179 - 188
[10] Animal Models of Parkinson's Disease: Limits and Relevance to Neuroprotection Studies
Bezard, Erwan
Yue, Zhenyu
Kirik, Deniz
Spillantini, Maria Grazia
[J]. MOVEMENT DISORDERS, 2013, 28 (01) : 61 - 70

← 1 2 3 4 5 6 7 8 →