Royal Jelly Prevents the Progression of Sarcopenia in Aged Mice In Vivo and In Vitro

被引：43

作者：

Niu, Kaijun ^{[1
,2
]}

Guo, Hui ^{[3
]}

Guo, Yinting ^{[4
]}

Ebihara, Satoru ^{[5
]}

Asada, Masanori ^{[6
]}

Ohrui, Takashi ^{[7
]}

Furukawa, Katsutoshi ^{[6
]}

Ichinose, Masakazu ^{[8
]}

Yanai, Kazuhiko ^{[9
]}

Kudo, Yukitsuka ^{[10
]}

Arai, Hiroyuki ^{[6
]}

Okazaki, Tatsuma ^{[8
]}

Nagatomi, Ryoichi ^{[2
]}

机构：

[1] Tianjin Med Univ, Sch Publ Hlth, Dept Nutr & Food Sci, Lab Nutrit Epidemiol, Tianjin 300070, Peoples R China

[2] Tohoku Univ, Grad Sch Biomed Engn, Div Biomed Engn Hlth & Welf, Sendai, Miyagi 980, Japan

[3] Tianjin Univ Sport, Tianjin, Peoples R China

[4] Tohoku Univ, Grad Sch Med, Dept Behav Med, Sendai, Miyagi 980, Japan

[5] Tohoku Univ, Grad Sch Med, Dept Internal Med & Rehabil Sci, Sendai, Miyagi 980, Japan

[6] Tohoku Univ, Inst Dev Aging & Canc, Dept Geriatr & Gerontol, Div Brain Sci, Sendai, Miyagi 980, Japan

[7] Tohoku Univ, Inst Dev Aging & Canc, Div Geriatr Pharmacotherapy, Sendai, Miyagi 980, Japan

[8] Tohoku Univ Hosp, Dept Resp Med, Sendai, Miyagi, Japan

[9] Tohoku Univ, Grad Sch Med, Dept Pharmacol, Sendai, Miyagi 980, Japan

[10] Tohoku Univ Hosp, Innovat & Educ Ctr, Sendai, Miyagi, Japan

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2013年 / 68卷 / 12期

关键词：

Aged mice; Sarcopenia; Satellite cells; Royal jelly; Insulin-like growth factor-1; Akt signaling; GROWTH-FACTOR-I; SKELETAL-MUSCLE; SATELLITE CELLS; LIFE-SPAN; NUTRITIONAL-STATUS; INSULIN; ANGIOGENESIS; MODULATION; SURVIVAL; RECEPTOR;

D O I：

10.1093/gerona/glt041

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Sarcopenia is characterized by the age-related loss of muscle mass and strength. One of the mechanisms of sarcopenia is the loss in the function and number of muscle satellite cells. Royal jelly (RJ) is a health food used worldwide. To obtain better digestion and absorption than RJ, protease-treated RJ (pRJ) has been developed. RJ and pRJ have been suggested to have potential pharmacological benefits such as prolonging the life span and reducing fatigue. Because these effects may improve sarcopenia and the functions of satellite cells, we examined the effects of RJ or pRJ treatment on the skeletal muscles in an animal model using aged mice. In vivo, RJ/pRJ treatment attenuated the decrease in the muscle weight and grip strength and increased the regenerating capacity of injured muscles and the serum insulin-like growth factor-1 levels compared with controls. In vitro, using isolated satellite cells from aged mice, pRJ treatment increased the cell proliferation rate, promoted cell differentiation, and activated Akt intracellular signaling pathway compared with controls. These findings suggest that RJ/pRJ treatment had a beneficial effect on age-related sarcopenia.

引用

页码：1482 / 1492

页数：11

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