Granzymes in age-related cardiovascular and pulmonary diseases

被引：55

作者：

Hendel, A. ^{[1
]}

Hiebert, P. R. ^{[1
]}

Boivin, W. A. ^{[1
]}

Williams, S. J. ^{[1
]}

Granville, D. J. ^{[1
]}

机构：

[1] Univ British Columbia, St Pauls Hosp, Dept Pathol & Lab Med, Providence Heart Lung Inst, Vancouver, BC V6Z 1Y6, Canada

来源：

CELL DEATH AND DIFFERENTIATION | 2010年 / 17卷 / 04期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

granzymes; inflammation; COPD; aging; aneurysm; extracellular matrix; SERINE-PROTEASE GRANZYME; CYTOTOXIC T-LYMPHOCYTES; EXTRACELLULAR ACTIVITIES; ACTIVATED RECEPTOR-2; HUMAN KERATINOCYTES; THROMBIN RECEPTOR; CELL APOPTOSIS; CUTTING EDGE; NITRIC-OXIDE; INFLAMMATION;

D O I：

10.1038/cdd.2010.5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic inflammation is a hallmark of age-related cardiovascular and pulmonary diseases. Granzymes are a family of serine proteases that have been traditionally viewed as initiators of immune-mediated cell death. However, recent findings suggest that the pathophysiological role of granzymes is complex. Emerging functions for granzymes in extracellular matrix degradation, autoimmunity, and inflammation suggests a multifactorial mechanism by which these enzymes are capable of mediating tissue damage. Recent discoveries showing that granzymes can be produced and secreted by nonimmune cells during disease provide an additional layer of intricacy. This review examines the emerging biochemical and clinical evidence pertaining to intracellular and/or extracellular granzymes in the pathogenesis of aging and cardiopulmonary diseases. Cell Death and Differentiation (2010) 17, 596-606; doi: 10.1038/cdd.2010.5; published online 5 February 2010

引用

页码：596 / 606

页数：11

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